Activity-dependent mapping in the retinotectal projection.

TitleActivity-dependent mapping in the retinotectal projection.
Publication TypeJournal Article
Year of Publication2002
JournalCurrent opinion in neurobiology
Volume12
Issue1
Pagination93-9
ISSN0959-4388
Abstract

It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0959438802002957
Short TitleCurr Opin Neurobiol
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