BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
|Title||BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.|
|Publication Type||Journal Article|
|Year of Publication||2017|
Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.