BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.

  • Assistant Professor
  • Bioinformatics and Computational Biology
  • Biology
  • Cell and Developmental Biology
  • Ecology and Evolutionary Biology
  • Genetics and Genomics
311 Thomas Hunt Morgan
(859) 257-0124
TitleBVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
Publication TypeJournal Article
Year of Publication2017
JournalGut
Volume66
Issue5
Pagination852-862
ISSN0017-5749
Abstract

Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.

URLhttp://gut.bmj.com/cgi/pmidlookup?view=long&pmid=28389570
DOI10.1136/gutjnl-2015-310255
Short TitleGut
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