Capn5 Expression in the Healthy and Regenerating Zebrafish Retina.

TitleCapn5 Expression in the Healthy and Regenerating Zebrafish Retina.
Publication TypeJournal Article
Year of Publication2018
JournalInvestigative ophthalmology & visual science
Volume59
Issue8
Pagination3643-3654
Date Published2018
ISSN0146-0404
Abstract

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a devastating inherited autoimmune disease of the eye that displays features commonly seen in other eye diseases, such as retinitis pigmentosa and diabetic retinopathy. ADNIV is caused by a gain-of-function mutation in Calpain-5 (CAPN5), a calcium-dependent cysteine protease. Very little is known about the normal function of CAPN5 in the adult retina, and there are conflicting results regarding its role during mammalian embryonic development. The zebrafish (Danio rerio) is an excellent animal model for studying vertebrate development and tissue regeneration, and represents a novel model to explore the function of Capn5 in the eye.

URLhttp://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.18-24278
DOI10.1167/iovs.18-24278
Short TitleInvest Ophthalmol Vis Sci
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