Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.

TitleDeveloping a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.
Publication TypeJournal Article
Year of Publication2019
JournalThe Journal of surgical research
Volume234
Pagination13-19
ISSN0022-4804
Abstract

Short bowel syndrome (SBS) results from extensive bowel resection. Patients with SBS require total parenteral nutrition (TPN) for survival. Understanding mechanisms contributing to TPN-associated liver injury and gut atrophy are critical in developing SBS therapies. Existing SBS models using tethered animals have significant limitations and are unlike ambulatory human SBS patients. We hypothesized that we could induce SBS in piglets and develop an ambulatory TPN-SBS model.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0022-4804(18)30611-5
DOI10.1016/j.jss.2018.08.042
Short TitleJ Surg Res
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