Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice.

TitleDistinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice.
Publication TypeJournal Article
Year of Publication2012
JournalSleep
Volume35
Issue10
Pagination1385-94
Date Published2012
ISSN0161-8105
Abstract

We have previously established that CAST/EiJ (CAST) mice differ from normal mice, such as C57BL/6J (B6), in the timing of wheel-running onset relative to light/dark cycles. These mice provide an animal model for studies of the genetic and neurobiological basis for circadian phase misalignment in humans. Neither differences in endogenous circadian period nor the shape of the photic phase response curve explain the difference in the timing of activity onset between CAST and B6 mice, suggesting a mechanism downstream of the circadian clock. Here, we further test the hypothesis that the two strains differ with respect to circadian oscillations at the molecular level.

URLhttps://academic.oup.com/sleep/article-lookup/doi/10.5665/sleep.2120
DOI10.5665/sleep.2120
Short TitleSleep
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading