The Drosophila HOAP protein is required for telomere capping.

TitleThe Drosophila HOAP protein is required for telomere capping.
Publication TypeJournal Article
Year of Publication2003
JournalNature cell biology
Volume5
Issue1
Pagination82-4
ISSN1465-7392
Abstract

HOAP (HP1/ORC-associated protein) has recently been isolated from Drosophila melanogaster embryos as part of a cytoplasmic complex that contains heterochromatin protein 1 (HP1) and the origin recognition complex subunit 2 (ORC2). Here, we show that caravaggio, a mutation in the HOAP-encoding gene, causes extensive telomere-telomere fusions in larval brain cells, indicating that HOAP is required for telomere capping. Our analyses indicate that HOAP is specifically enriched at mitotic chromosome telomeres, and strongly suggest that HP1 and HOAP form a telomere-capping complex that does not contain ORC2.

URLhttp://dx.doi.org/10.1038/ncb902
DOI10.1038/ncb902
Short TitleNat Cell Biol
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