Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.

TitleEffects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
Publication TypeJournal Article
Year of Publication2017
JournalGastroenterology
Volume153
Issue3
Pagination743-752
ISSN0016-5085
Abstract

Consumption of sugar is associated with obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular disease. The conversion of fructose to fat in liver (de novo lipogenesis [DNL]) may be a modifiable pathogenetic pathway. We determined the effect of 9 days of isocaloric fructose restriction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual high sugar consumption (fructose intake >50 g/d).

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0016-5085(17)35685-8
DOI10.1053/j.gastro.2017.05.043
Short TitleGastroenterology
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