Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro.

TitleEffects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro.
Publication TypeJournal Article
Year of Publication1989
JournalNeuroscience letters
Volume97
Issue1-2
Pagination140-4
Date Published1989
ISSN0304-3940
Abstract

The pineal hormone melatonin is believed to act directly on the hypothalamic suprachiasmatic nuclei (SCN), which are principal circadian pacemakers in rodents, although direct demonstration of this is lacking. To determine whether the SCN are sensitive to melatonin electrophysiologically, we investigated the effect of melatonin on rat SCN single-unit activity in an in vitro hypothalamic slice preparation. SCN single-unit activity was inhibited by melatonin superfusion during the late subjective day in a dose-dependent manner but not at other times of day, supporting the view that melatonin acts directly on SCN neurons.

URLhttps://linkinghub.elsevier.com/retrieve/pii/0304-3940(89)90153-5
Short TitleNeurosci Lett
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