Immortal time: circadian clock properties of rat suprachiasmatic cell lines.

TitleImmortal time: circadian clock properties of rat suprachiasmatic cell lines.
Publication TypeJournal Article
Year of Publication1999
JournalScience (New York, N.Y.)
Volume283
Issue5402
Pagination693-5
Date Published1999
ISSN0036-8075
Abstract

Cell lines derived from the rat suprachiasmatic nucleus (SCN) were screened for circadian clock properties distinctive of the SCN in situ. Immortalized SCN cells generated robust rhythms in uptake of the metabolic marker 2-deoxyglucose and in their content of neurotrophins. The phase relationship between these rhythms in vitro was identical to that exhibited by the SCN in vivo. Transplantation of SCN cell lines, but not mesencephalic or fibroblast lines, restored the circadian activity rhythm in arrhythmic, SCN-lesioned rats. Thus, distinctive oscillator, pacemaker, and clock properties of the SCN are not only retained but also maintained in an appropriate circadian phase relationship by immortalized SCN progenitors.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=9924030
Short TitleScience
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