MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression.

TitleMHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression.
Publication TypeJournal Article
Year of Publication1998
JournalAmerican journal of reproductive immunology (New York, N.Y. : 1989)
Volume40
Issue6
Pagination385-94
ISSN1046-7408
Abstract

Major histocompatibility complex (MHC) class II molecule expression is specifically suppressed on fetal trophoblasts, even in response to interferon (IFN)-gamma, a potent inducer of MHC class II genes. The suppression of class II induction has been suggested to play a role in preventing rejection of the fetal allograft. The mechanism of this suppression is unknown.

URLhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1046-7408&date=1998&volume=40&issue=6&spage=385
Short TitleAm J Reprod Immunol
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