Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.

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  • Biology
  • Cell and Developmental Biology
  • Ecology and Evolutionary Biology
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TitleMolecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.
Publication TypeJournal Article
Year of Publication2016
JournalThe Journal of urology
Volume196
Issue4
Pagination1295-302
ISSN0022-5347
Abstract

Lower urinary tract malformations are among the most common congenital anomalies in humans. Molecular genetic studies of mouse external genital development have begun to identify mechanisms that pattern the genital tubercle and orchestrate urethral tubulogenesis. The urethral plate epithelium is an endodermal signaling region that has an essential role in external genital development. However, little is known about the molecular identity of this cell population or the genes that regulate its activity.

URLhttps://linkinghub.elsevier.com/retrieve/pii/S0022-5347(16)30364-0
DOI10.1016/j.juro.2016.04.091
Short TitleJ Urol
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