Nitric oxide synthase inhibition impairs muscle regrowth following immobilization.

TitleNitric oxide synthase inhibition impairs muscle regrowth following immobilization.
Publication TypeJournal Article
Year of Publication2017
JournalNitric oxide : biology and chemistry
Date Published2017

Nitric oxide (NO) has been shown to increase skeletal muscle protein synthesis. However, the role of NO during skeletal muscle regrowth after immobilization remains unknown. The purpose of this study was to determine whether NO is required for muscle regrowth/recovery after a period of disuse by immobilization. Male Wistar rats were divided into 4 groups: recovered, 1-(2-trifluoromethyl-phenyl)-imidazole (TRIM; 10 mg·kg body mass·day), N-nitro-l-arginine methyl ester (l-NAME; 90 mg·kg body mass·day), and control. The recovered, TRIM, l-NAME groups were submitted to a 7-d muscle recovery period (by remobilization), following a 10-d immobilization period (to induce plantaris [PLA] muscle atrophy). After the experimental period, the PLA muscle was collected for morphometrical (muscle fibers cross-sectional area [CSA]) and molecular (Phospho-mTOR protein expression) analysis. After 7 d of recovery, the recovered group displayed complete muscle regrowth (CSA, recovered: 2.216 ± 214 vs.

Short TitleNitric Oxide
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