Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.

TitleNovel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.
Publication TypeJournal Article
Year of Publication2018
JournalJournal of neuroinflammation
Volume15
Issue1
Pagination154
Date Published2018
Abstract

Traumatic brain injury (TBI) begins with the application of mechanical force to the head or brain, which initiates systemic and cellular processes that are hallmarks of the disease. The pathological cascade of secondary injury processes, including inflammation, can exacerbate brain injury-induced morbidities and thus represents a plausible target for pharmaceutical therapies. We have pioneered research on post-traumatic sleep, identifying that injury-induced sleep lasting for 6 h in brain-injured mice coincides with increased cortical levels of inflammatory cytokines, including tumor necrosis factor (TNF). Here, we apply post-traumatic sleep as a physiological bio-indicator of inflammation. We hypothesized the efficacy of novel TNF receptor (TNF-R) inhibitors could be screened using post-traumatic sleep and that these novel compounds would improve functional recovery following diffuse TBI in the mouse.

URLhttps://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1200-y
DOI10.1186/s12974-018-1200-y
Short TitleJ Neuroinflammation
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