On the origin and spread of an adaptive allele in deer mice.

TitleOn the origin and spread of an adaptive allele in deer mice.
Publication TypeJournal Article
Year of Publication2009
JournalScience (New York, N.Y.)
Volume325
Issue5944
Pagination1095-8
Date Published2009
ISSN0036-8075
Abstract

Adaptation is a central focus of biology, although it can be difficult to identify both the strength and agent of selection and the underlying molecular mechanisms causing change. We studied cryptically colored deer mice living on the Nebraska Sand Hills and show that their light coloration stems from a novel banding pattern on individual hairs produced by an increase in Agouti expression caused by a cis-acting mutation (or mutations), which either is or is closely linked to a single amino acid deletion in Agouti that appears to be under selection. Furthermore, our data suggest that this derived Agouti allele arose de novo after the formation of the Sand Hills. These findings reveal one means by which genetic, developmental, and evolutionary mechanisms can drive rapid adaptation under ecological pressure.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=19713521
DOI10.1126/science.1175826
Short TitleScience
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