Origins of serotonin-like immunoreactivity in the optic tectum of Rana pipiens.

TitleOrigins of serotonin-like immunoreactivity in the optic tectum of Rana pipiens.
Publication TypeJournal Article
Year of Publication1995
JournalThe Journal of comparative neurology
Volume352
Issue2
Pagination280-96
Date Published1995
ISSN0021-9967
Abstract

We have previously identified a population of serotonin-like immunoreactive (5-HT-ir) retinal ganglion cells in Rana pipiens. In this study, we examined serotonin-like immunoreactivity (5-HTLI) in a probable target of those cells, the optic tectum. We observed both 5-HT-ir fibers and cell bodies in this structure. 5-HT-ir cells were located in the cellular layers of the tectum, layers 2, 4, and 6, and scattered in its superficial layers. 5-HT-ir fibers in the tectum displayed a laminated organization and were located in tectal layers 3, 5, 6, 7, and 9. Retrograde labelling experiments showed that 5-HT-ir retinal ganglion cells projected to the optic tectum. However, these experiments also demonstrated that serotonergic neurons in the midbrain tegmentum, the nucleus isthmi, and the medulla did so as well. 5-HT-ir fibers seen in lamina A of layer 9 were very much reduced in density in animals in which the optic nerve had been lesioned for 3-6 months. Immunoreactive fibers in lamina B of layer 9 were not affected by the lesion. Our results suggest that 5-HT-ir fibers in lamina A of layer 9 are mainly of retinal origin, whereas those in lamina B originate from other brain areas. The 5-HT-ir tectal cells located in the cellular layers probably contribute the 5-HT-ir fibers seen in layers 3, 5, 6, and 7.

URLhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0021-9967&date=1995&volume=352&issue=2&spage=280
DOI10.1002/cne.903520210
Short TitleJ Comp Neurol
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