The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.

TitleThe sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.
Publication TypeJournal Article
Year of Publication2018
JournalNature genetics
Volume50
Issue2
Pagination270-277
ISSN1061-4036
Abstract

The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing vertebrate evolution. To enable more informed analyses, we developed a new assembly of the lamprey germline genome that integrates several complementary data sets. Analysis of this highly contiguous (chromosome-scale) assembly shows that both chromosomal and whole-genome duplications have played significant roles in the evolution of ancestral vertebrate and lamprey genomes, including chromosomes that carry the six lamprey HOX clusters. The assembly also contains several hundred genes that are reproducibly eliminated from somatic cells during early development in lamprey. Comparative analyses show that gnathostome (mouse) homologs of these genes are frequently marked by polycomb repressive complexes (PRCs) in embryonic stem cells, suggesting overlaps in the regulatory logic of somatic DNA elimination and bivalent states that are regulated by early embryonic PRCs. This new assembly will enhance diverse studies that are informed by lampreys' unique biology and evolutionary/comparative perspective.

URLhttp://dx.doi.org/10.1038/s41588-017-0036-1
DOI10.1038/s41588-017-0036-1
Short TitleNat Genet
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