Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.

TitleSiah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
Publication TypeJournal Article
Year of Publication2010
JournalScience (New York, N.Y.)
Volume330
Issue6012
Pagination1834-8
Date Published2010
ISSN0036-8075
Abstract

The brain's circuitry is established by directed migration and synaptogenesis of neurons during development. Although neurons mature and migrate in specific patterns, little is known about how neurons exit their germinal zone niche. We found that cerebellar granule neuron germinal zone exit is regulated by proteasomal degradation of Pard3A by the Seven in Absentia homolog (Siah) E3 ubiquitin ligase. Pard3A gain of function and Siah loss of function induce precocious radial migration. Time-lapse imaging using a probe to measure neuronal cell contact reveals that Pard3A promotes adhesive interactions needed for germinal zone exit by recruiting the epithelial tight junction adhesion molecule C to the neuronal cell surface. Our findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=21109632
DOI10.1126/science.1198480
Short TitleScience
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