A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae.

TitleA systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae.
Publication TypeJournal Article
Year of Publication2008
JournalNature methods
Volume5
Issue3
Pagination239-41
ISSN1548-7091
Abstract

Modern genetic analysis requires the development of new resources to systematically explore gene function in vivo. Overexpression screens are a powerful method to investigate genetic pathways, but the goal of routine and comprehensive overexpression screens has been hampered by the lack of systematic libraries. Here we describe the construction of a systematic collection of the Saccharomyces cerevisiae genome in a high-copy vector and its validation in two overexpression screens.

URLhttp://dx.doi.org/10.1038/nmeth.1181
DOI10.1038/nmeth.1181
Short TitleNat Methods
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