Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities.

TitleTwo Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities.
Publication TypeJournal Article
Year of Publication2004
JournalBMC cell biology
Volume5
Issue1
Pagination38
Date Published2004
Abstract

The Janus kinase (JAK) cascade is an essential and well-conserved pathway required to transduce signals for a variety of ligands in both vertebrates and invertebrates. While activation of the pathway is essential to many processes, mutations from mammals and Drosophila demonstrate that regulation is also critical. The SOCS (Suppressor Of Cytokine Signaling) proteins in mammals are regulators of the JAK pathway that participate in a negative feedback loop, as they are transcriptionally activated by JAK signaling. Examination of one Drosophila SOCS homologue, Socs36E, demonstrated that its expression is responsive to JAK pathway activity and it is capable of downregulating JAK signaling, similar to the well characterized mammalian SOCS.

URLhttps://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2121-5-38
DOI10.1186/1471-2121-5-38
Short TitleBMC Cell Biol
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