Ph.D. Univ. of California at Davis, 1983
Nuclear Receptor Signaling
The experimental questions that I am addressing concern the molecular players and mechanisms through which hormones regulate the developmental programs of gene expression that control cellular commitment. The model system in which I experimentally dissect these mechanisms is the program of metamorphic transition of insect tissues from the immature to the adult state of differentiation, as controlled by the nuclear action of (retinoid-like) juvenile hormone and (the steroidal) ecdysteroids. In these investigations I employ the pertinent techniques that are needed to address the particular mechanistic question at issue, ranging from molecular and biochemical to genetic and germline transformation approaches. My recent studies have attended the structure and molecular interactions of hormone receptors with other transcription factors, including the basal transcription apparatus, in transduction of the ligand-binding signal.
- "Research residents' perceptions of skill decay: Effects of repeated skills assessments and scenario difficulty." American journal of surgery (2016): Details. Full text
- "Lay Epistemology of Breast Cancer Screening Guidelines Among Appalachian Women." Health communication (2016): 1-9. Details.
- "Identification of methyl farnesoate from the hemolymph of insects." Journal of natural products 77, 2 (2014): 402-5. Details. Full text
- "Sesquiterpene action, and morphogenetic signaling through the ortholog of retinoid X receptor, in higher Diptera." General and comparative endocrinology 194, (2013): 326-35. Details. Full text
- "Ligand binding pocket function of Drosophila USP is necessary for metamorphosis." General and comparative endocrinology 182, (2013): 73-82. Details. Full text
- "Juvenile hormone action through a defined enhancer motif to modulate ecdysteroid-activation of natural core promoters." Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 161, 3 (2012): 219-25. Details. Full text
- "Suppressed production of methyl farnesoid hormones yields developmental defects and lethality in Drosophila larvae." General and comparative endocrinology 165, 2 (2010): 244-54. Details. Full text
- "Activities of natural methyl farnesoids on pupariation and metamorphosis of Drosophila melanogaster." Journal of insect physiology 56, 10 (2010): 1456-64. Details. Full text
- "A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae." Nature methods 5, 3 (2008): 239-41. Details. Full text
- "Farnesoid secretions of dipteran ring glands: what we do know and what we can know." Insect biochemistry and molecular biology 37, 8 (2007): 771-98. Details. Full text
- "The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand." The FEBS journal 273, 21 (2006): 4983-96. Details. Full text
- "Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling." The FEBS journal 272, 7 (2005): 1577-89. Details. Full text
- "Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle." Insect biochemistry and molecular biology 34, 11 (2004): 1147-62. Details. Full text
- "A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells." DNA and cell biology 23, 7 (2004): 419-29. Details. Full text
- "A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells." DNA and cell biology 23, 9 (2004): 527-37. Details. Full text
- "Bring back dedicated, caring nurses." Nursing standard (Royal College of Nursing (Great Britain) : 1987) 17, 7 (2002): 30. Details.
- "Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle." European journal of biochemistry 269, 24 (2002): 6026-36. Details. Full text
- "Juvenile hormone binding protein core promoter is TATA-driven with a suppressory element." Biochimica et biophysica acta 1809, 4-6 (1969): 226-35. Details. Full text
- "Using communication to manage uncertainty about cervical cancer screening guideline adherence among Appalachian women." Journal of applied communication research : JACR 44, 1 (0): 22-39. Details.