Jeffrey L. Osborn

  • Professor
  • Biology
  • Biology Education
  • Environmental and Sustainability Studies
  • Neuroscience and Neurobiology
  • Physiology
115A TH Morgan Building
(859) 257-3988
Research Interests:
Education

B.A. Amherst College; M.S. Michigan State Univ., 1976; Ph.D. Michigan State Univ., 1979; Posdoctoral Fellow, Cardiovascular Research Inst., Dept. of Internal Medicine, University of Iowa '79-'81

Research

The laboratory of Dr. Jeffrey Osborn at the University of Kentucky Department of Biology provides a specialized environment where all students experience "science in action". The physiological research laboratory focuses upon the neural control of renal sodium and water balance and the role of renal sympathetic nerves in the control of blood pressure. Current studies involve studying brain angiotensin II, sodium intake and how renal nerves affect kidney function and blood pressure in a variety of species and environmental conditions. The educational research program focuses upon: 1) providing school districts, teachers and students with the resources and tools for stimulating students to "learn science as scientific research is conducted"; 2) teachers and students linking with university resources through the Appalachian Math Science Partnership; 3) improving student achievement through the Appalachian Minority Science, Technology, Engineering and Math Majors Program (AMSTEMM), 4) and Newton's Universe: conducting educational research on how technology and new methods of distance learning can increase K-12 student achievement in rural and Appalachian schools.Newton’s Universe is a major NSF funded project that focuses on physics and technology for middle school teachers and their students.  The project’s main purpose is to enhance rural middle school students’ understanding of standards based physics concepts. The project accomplishes this by enhancing teachers’ understanding in physics through a series of distance learning courses designed specifically for teachers.  At the same time it provides tools, strategies and activities for learning through inquiry and integrating technology as a key part of that learning. 

 

PubMed Publications*: 
  • Franklin, BM ;Voss, SR ;Osborn, JL "Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration." Mechanisms of development 146, (2017): 42-54. Details. Full text
  • Loria, AS ;Osborn, JL "Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats." American journal of physiology. Renal physiology 313, 1 (2017): F47-F54. Details. Full text
  • Rhoads, MK ;Goleva, SB ;Beierwaltes, WH ;Osborn, JL "Renal vascular and glomerular pathologies associated with spontaneous hypertension in the nonhuman primate <i>Chlorocebus aethiops sabaeus</i>." American journal of physiology. Regulatory, integrative and comparative physiology 313, 3 (2017): R211-R218. Details. Full text
  • Franklin, BM ;Maroudas, E ;Osborn, JL "Sine-wave electrical stimulation initiates a voltage-gated potassium channel-dependent soft tissue response characterized by induction of hemocyte recruitment and collagen deposition." Physiological reports 4, 12 (2016): Details. Full text
  • Franklin, BM ;Xiang, L ;Collett, JA ;Rhoads, MK ;Osborn, JL "Open problem-based instruction impacts understanding of physiological concepts differently in undergraduate students." Advances in physiology education 39, 4 (2015): 327-34. Details. Full text
  • Collett, JA ;Hart, AK ;Patterson, E ;Kretzer, J ;Osborn, JL "Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome." Physiological reports 1, 5 (2013): e00104. Details. Full text
  • Osborn, JL ;Sacks, R. "Chapter 2: Nasal obstruction." American journal of rhinology & allergy 27, 3 (2013): 7-8. Details. Full text
  • Ramachandran, S.;Singhal, M.;McKenzie, KG ;Osborn, JL ;Arjyal, A.;Dongol, S ;Baker, SG ;Basnyat, B ;Farrar, J ;Dolecek, C ;Domingo, GJ ;Yager, P.;Lutz, B. "A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA." Diagnostics (Basel, Switzerland) 3, 2 (2013): 244-60. Details. Full text
  • Stocker, SD ;Osborn, JL ;Carmichael, SP "Forebrain osmotic regulation of the sympathetic nervous system." Clinical and experimental pharmacology & physiology 35, 5-6 (2008): 695-700. Details. Full text
  • Basile, DP ;Donohoe, D.;Roethe, K.;Osborn, JL "Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function." American journal of physiology. Renal physiology 281, 5 (2001): F887-99. Details. Full text
  • Camara, AK ;Osborn, JL "Alpha-adrenergic systems mediate chronic central AII hypertension in rats fed high sodium chloride diet from weaning." Journal of the autonomic nervous system 76, 1 (1999): 28-34. Details. Full text
  • Camara, AK ;Osborn, JL "AT1 receptors mediate chronic central nervous system AII hypertension in rats fed high sodium chloride diet from weaning." Journal of the autonomic nervous system 72, 1 (1998): 16-23. Details. Full text
  • Osborn, JL ;Plato, CF ;Gordin, E.;He, XR "Long-term increases in renal sympathetic nerve activity and hypertension." Clinical and experimental pharmacology & physiology 24, 1 (1997): 72-6. Details. Full text
  • Osborn, JL ;Camara, AK "Renal neurogenic mediation of intracerebroventricular angiotensin II hypertension in rats raised on high sodium chloride diet." Hypertension (Dallas, Tex. : 1979) 30, 3 Pt 1 (1997): 331-6. Details. Full text
  • Plato, CF ;Osborn, JL "Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction." Hypertension (Dallas, Tex. : 1979) 28, 6 (1996): 1034-40. Details. Full text
  • Johnson, CP ;Sarna, SK ;Cowles, VE ;Osborn, JL ;Zhu, YR ;Bonham, L.;Buchmann, E.;Baytiyeh, R.;Telford, GL ;Roza, AM "Motor activity and transit in the autonomically denervated jejunum." American journal of surgery 167, 1 (1994): 80-8. Details. Full text
  • Greenberg, S.;Osborn, JL "Relationship between sodium balance and renal innervation during hypertension development in the spontaneously hypertensive rat." Journal of hypertension 12, 12 (1994): 1359-64. Details.
  • Song, CW ;Makepeace, CM ;Griffin, RJ ;Hasegawa, T.;Osborn, JL ;Choi, IB ;Nah, BS "Increase in tumor blood flow by pentoxifylline." International journal of radiation oncology, biology, physics 29, 3 (1994): 433-7. Details. Full text
  • Prager, NA ;Cox, JL ;Lindsay, BD ;Ferguson TB, Jr ;Osborn, JL ;Cain, ME "Long-term effectiveness of surgical treatment of ectopic atrial tachycardia." Journal of the American College of Cardiology 22, 1 (1993): 85-92. Details. Full text
  • Nelson, LD ;Osborn, JL "Neurogenic control of renal function in response to graded nonhypotensive hemorrhage in conscious dogs." The American journal of physiology 264, 4 Pt 2 (1993): R661-7. Details. Full text
  • Nelson, LD ;Osborn, JL "Role of intrarenal ANG II in reflex neural stimulation of plasma renin activity and renal sodium reabsorption." The American journal of physiology 265, 2 Pt 2 (1993): R392-8. Details. Full text
  • Greenberg, SG ;Enders, C.;Osborn, JL "Renal nerves affect rate of achieving sodium balance in spontaneously hypertensive rats." Hypertension (Dallas, Tex. : 1979) 22, 1 (1993): 1-8. Details. Full text
  • Lindsay, BD ;Chung, MK ;Gamache, MC ;Luke, RA ;Schechtman, KB ;Osborn, JL ;Cain, ME "Therapeutic end points for the treatment of atrioventricular node reentrant tachycardia by catheter-guided radiofrequency current." Journal of the American College of Cardiology 22, 3 (1993): 733-40. Details. Full text
  • Lindsay, BD ;Osborn, JL ;Schechtman, KB ;Kenzora, JL ;Ambos, HD ;Cain, ME "Prospective detection of vulnerability to sustained ventricular tachycardia in patients awaiting cardiac transplantation." The American journal of cardiology 69, 6 (1992): 619-24. Details. Full text
  • Greenberg, SG ;Tershner, S.;Osborn, JL "Neurogenic regulation of rate of achieving sodium balance after increasing sodium intake." The American journal of physiology 261, 2 Pt 2 (1991): F300-7. Details. Full text
  • Dawson, CA ;Cowley AW, Jr ;Spurr, GB ;Osborn, JL ;Raff, H.;Forster, HV ;Harder, DR ;Liard, JF ;Lombard, JH ;Stekiel, WJ "Performance on multiple choice/short answer tests is not a sufficient criterion for evaluating the educational value of live animal laboratories in the teaching of physiology." The American journal of physiology 261, 6 Pt 3 (1991): S34-5. Details. Full text
  • Osborn, JL "Relation between sodium intake, renal function, and the regulation of arterial pressure." Hypertension (Dallas, Tex. : 1979) 17, 1 Suppl (1991): I91-6. Details.
  • Lombard, JH ;Eskinder, H.;Kauser, K.;Osborn, JL ;Harder, DR "Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure." The American journal of physiology 259, 1 Pt 2 (1990): H29-33. Details. Full text
  • Uda, M.;Osborn, JL ;Lee, CK ;Nakhleh, RE ;Song, CW "Pathophysiological changes after local heating of rat liver." International journal of radiation oncology, biology, physics 18, 3 (1990): 587-94. Details. Full text
  • Marsh, DJ ;Osborn, JL ;Cowley AW, Jr "1/f fluctuations in arterial pressure and regulation of renal blood flow in dogs." The American journal of physiology 258, 5 Pt 2 (1990): F1394-400. Details. Full text
  • O'Hair, DP ;Adams, MB ;Tunberg, TC ;Osborn, JL "Relationships among endotoxemia, arterial pressure, and renal function in dogs." Circulatory shock 27, 3 (1989): 199-210. Details.
  • Osborn, JL ;Curro, TG "Renal sympathetic nerve activity and arterial pressure responses to changes in postural position of conscious dogs." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 192, 3 (1989): 248-54. Details.
  • Osborn, JL ;Roman, RJ ;Ewens, JD "Renal nerves and the development of Dahl salt-sensitive hypertension." Hypertension (Dallas, Tex. : 1979) 11, 6 Pt 1 (1988): 523-8. Details. Full text
  • Osborn, JL ;Harland, RW "Alpha 1-adrenoceptor mediation of urinary bicarbonate excretion." The American journal of physiology 255, 6 Pt 2 (1988): F1116-21. Details. Full text
  • Roman, RJ ;Osborn, JL "Renal function and sodium balance in conscious Dahl S and R rats." The American journal of physiology 252, 5 Pt 2 (1987): R833-41. Details. Full text
  • Osborn, JL ;Kinstetter, DD "Effects of altered NaCl intake on renal hemodynamic and renin release responses to RNS." The American journal of physiology 253, 5 Pt 2 (1987): F976-81. Details. Full text
  • Cowley AW, Jr ;Barber, WJ ;Lombard, JH ;Osborn, JL ;Liard, JF "Relationship between body fluid volumes and arterial pressure." Federation proceedings 45, 13 (1986): 2864-70. Details.
  • Osborn, JL ;Lawton, MT "Neurogenic antinatriuresis during development of acute cardiac tamponade." The American journal of physiology 250, 2 Pt 2 (1986): H195-201. Details. Full text
  • Osborn, JL ;Roman, RJ ;Harland, RW "Mechanisms of antinatriuresis during low-frequency renal nerve stimulation in anesthetized dogs." The American journal of physiology 249, 3 Pt 2 (1985): R360-7. Details. Full text
  • Seagard, JL ;Hopp, FA ;Bosnjak, ZJ ;Osborn, JL ;Kampine, JP "Sympathetic efferent nerve activity in conscious and isoflurane-anesthetized dogs." Anesthesiology 61, 3 (1984): 266-70. Details. Full text
  • Osborn, JL ;Kopp, UC ;Thames, MD ;DiBona, GF "Interactions among renal nerves, prostaglandins, and renal arterial pressure in the regulation of renin release." The American journal of physiology 247, 5 Pt 2 (1984): F706-13. Details. Full text
  • Osborn, JL ;Hoversten, LG ;DiBona, GF "Impaired blood flow autoregulation in nonfiltering kidneys: effects of theophylline administration." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 174, 3 (1983): 328-35. Details.
  • Osborn, JL ;Holdaas, H.;Thames, MD ;DiBona, GF "Renal adrenoceptor mediation of antinatriuretic and renin secretion responses to low frequency renal nerve stimulation in the dog." Circulation research 53, 3 (1983): 298-305. Details. Full text
  • Osborn, JL ;DiBona, GF ;Thames, MD "Role of renal alpha-adrenoceptors mediating renin secretion." The American journal of physiology 242, 6 (1982): F620-6. Details. Full text
  • Osborn, JL ;Thames, MD ;DiBona, GF "Role of macula densa in renal nerve modulation of renin secretion." The American journal of physiology 242, 3 (1982): R367-71. Details. Full text
  • Francisco, LL ;Osborn, JL ;DiBona, GF "Prostaglandin in renin release during sodium deprivation." The American journal of physiology 243, 6 (1982): F537-42. Details. Full text
  • Osborn, JL ;Thames, MD ;DiBona, GF "Renal nerves modulate renin secretion during autoregulation." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 169, 4 (1982): 432-7. Details.
  • DiBona, GF ;Johns, EJ ;Osborn, JL "The effect of vagotomy on sodium reabsorption and renin release in anaesthetized dogs subjected to 60 degrees head-up tilt." The Journal of physiology 320, (1981): 293-302. Details. Full text
  • Osborn, JL ;Kopp, UC ;DiBona, GF "Ischemic acute renal failure: newer implications of stopped pipes." The Journal of laboratory and clinical medicine 98, 1 (1981): 16-20. Details.
  • Osborn, JL ;Francisco, LL ;DiBona, GF "Effect of renal nerve stimulation on renal blood flow autoregulation and antinatriuresis during reductions in renal perfusion pressure." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 168, 1 (1981): 77-81. Details.
  • Osborn, JL ;DiBona, GF ;Thames, MD "Beta-1 receptor mediation of renin secretion elicited by low-frequency renal nerve stimulation." The Journal of pharmacology and experimental therapeutics 216, 2 (1981): 265-9. Details. Full text
  • Osborn, JL ;Hook, JB ;Bailie, MD "Effect of saralasin and indomethacin on renal function in developing piglets." The American journal of physiology 238, 5 (1980): R438-42. Details. Full text
  • Wallace, KB ;Osborn, JL ;Bailie, MD "Species differences in the kinetics of the renin-substrate reaction in plasma." Journal of pharmacological methods 4, 2 (1980): 141-54. Details.
  • Osborn, JL ;Noordewier, B.;Hook, JB ;Bailie, MD "Mechanism of prostaglandin E(2) stimulation of renin secretion." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 159, 2 (1978): 249-52. Details.
  • Osborn, JL ;Hook, JB ;Bailie, MD "Control of renin release. Effects of d-propranolol and renal denervation on furosemide-induced renin release in the dog." Circulation research 41, 4 (1977): 481-6. Details. Full text
  • Hook, JB ;Cardona, R.;Osborn, JL ;Bailie, MD ;Gehring, PJ "The renal handling of 2,4,5-trichlorophenoxy- acetic acid (2,4,5-T) in the dog." Food and cosmetics toxicology 14, 1 (1976): 19-23. Details.
  • Swart, GL ;Mateer, JR ;DeBehnke, DJ ;Jameson, SJ ;Osborn, JL "The effect of compression duration on hemodynamics during mechanical high-impulse CPR." Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1, 5 (1969): 430-7. Details. Full text
  • Osborn, JL ;Johns, EJ "Renal neurogenic control of renin and prostaglandin release." Mineral and electrolyte metabolism 15, 1-2 (0): 51-8. Details.
  • Collett, JA ;Paulose, JK ;Cassone, VM ;Osborn, JL "Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat." PloS one 10, 8 (0): e0136441. Details. Full text
  • Singleton, J ;Osborn, JL ;Lillis, L ;Hawkins, K ;Guelig, D ;Price, W ;Johns, R ;Ebels, K ;Boyle, D ;Weigl, B ;LaBarre, P "Electricity-free amplification and detection for molecular point-of-care diagnosis of HIV-1." PloS one 9, 11 (0): e113693. Details. Full text
  • Osborn, JL ;Hook, JB ;Bailie, MD "Regulation of plasma renin in developing piglets." Developmental pharmacology and therapeutics 1, 4 (0): 217-28. Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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