Jeffrey L. Osborn

jlosbo3's picture
  • Professor
  • Biology
  • Biology Education
  • Physiology
  • Neuroscience
115A TH Morgan Building
(859) 257-3988
Research Interests:
Education

B.A. Amherst College; M.S. Michigan State Univ., 1976; Ph.D. Michigan State Univ., 1979; Posdoctoral Fellow, Cardiovascular Research Inst., Dept. of Internal Medicine, University of Iowa '79-'81

Research

My research career has focused upon sympathetic neural control of renal function, regulation of salt and water balance and interactions among these controllers of renal function in the pathophysiology of blood pressure regulation and arterial hypertension. The overall hypothesis of our research program has been that environmental factors lead to elevated renal sympathetic nerve activity and alter kidney function, genetic expression and subsequently evoke renal dysfunction, arterial hypertension, and cardiovascular disease. Our most recent work examines the relationships among renal mitochondrial gene expression, inflammation, renal sympathetic nerve activity and the development of spontaneous hypertension.  Using a back cross breeding paradigm we produced a conplastic strain of offspring wherein the mitochondrial genome of spontaneously hypertensive rats (Aoki-Okamoto SHR) was inserted onto a background of nearly all nuclear genes from a normotensive Brown-Norway. In these rats, with 98% normotensive Brown Norway nuclear genome and 100% hypertensive SHR mitochondrial genome, hypertension persisted in the majority of animals. The hypertension was characterized and the level of salt sensitivity determined. We also evaluated the neurogenic components that contribute to the overall level of blood pressure in adulthood. We have now begun to determine the specific mitochondrial genetic loci responsible for this SHR-mediated mitochondrial hypertension. In addition, these hypertensive animals exhibited elevated renal and hypothalamic expression of angiotensin type 1 (AT1) receptors, suggesting a direct linkage between mitochondrial gene expression, and brain/kidney AT1 receptors.  This outcome aligns closely with our previous work that hypothalamic AT1 receptors are critical to neurogenic hypertension in rats raised on a high NaCl intake from weaning to adulthood. Our publication (PLoS One, 2015, 10(8): e0136441.doi:10.1371/journal.pone.0136441), shows selective renal downregulation of 11 out of 13 mitochondrially expressed genes in the hypertensive compared to normotensive animals.

We have now moved exclusively to understanding different renal and cardiovascular diseases related to translational, spontaneous hypertension in Chlorocebus aethiops sabeus or African Green Monkeys (Am. J. Physiol. Reg. Integ. Compar. Physiol. 313(3): R211-218, 2017). This unique model of spontaneous hypertension exhibits altered glomerulopathy, renal vascular wall thickening, myocardial hypertrophy and age related hypertension in both male and female animals. Furthermore, we have reported preliminary findings for C. aethiops exhibiting spontaneous gestational hypertension, early onset preeclampsia, downregulation of renal medullary mitochondrial genes and expression of the genetic variants of the APOL1 genes known to precede early onset end stage renal disease in African American humans. This new model of spontaneous hypertension in nonhuman primates will yield new insights into the development of human essential hypertension and provide the biomedical scientific community with a novel and necessary translational model for the long-term study of cardiovascular and end-stage renal disease.

PubMed Publications*: 
  • Anderson, GL ;Osborn, JL ;Nei, SD ;Bell, MR ;Barsness, GW ;Mara, KC ;Ou, NN "Comparison of In-Hospital Bleeding and Cardiovascular Events with High-Dose Bolus Tirofiban and Shortened Infusion to Short-Duration Eptifibatide as Adjunctive Therapy for Percutaneous Coronary Intervention." The American journal of cardiology 123, 1 (2019): 44-49. Details. Full text
  • Danelich, IM ;, ;Bergquist, WJ ;Osborn, JL ;Wright, SS ;Tefft, BJ ;Sturm, AW ;Langworthy, DR ;Mandrekar, J ;Devine, RM ;, ;Mathis, KL ;Pemberton, JH ;Jacob, AK ;Larson, DW "Early Diuresis After Colon and Rectal Surgery Does Not Reduce Length of Hospital Stay: Results of a Randomized Trial." Diseases of the colon and rectum 61, 10 (2018): 1187-1195. Details. Full text
  • Franklin, BM ;Voss, SR ;Osborn, JL "Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration." Mechanisms of development 146, (2017): 42-54. Details. Full text
  • Loria, AS ;Osborn, JL "Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats." American journal of physiology. Renal physiology 313, 1 (2017): F47-F54. Details. Full text
  • Rhoads, MK ;Goleva, SB ;Beierwaltes, WH ;Osborn, JL "Renal vascular and glomerular pathologies associated with spontaneous hypertension in the nonhuman primate <i>Chlorocebus aethiops sabaeus</i>." American journal of physiology. Regulatory, integrative and comparative physiology 313, 3 (2017): R211-R218. Details. Full text
  • Franklin, BM ;Maroudas, E ;Osborn, JL "Sine-wave electrical stimulation initiates a voltage-gated potassium channel-dependent soft tissue response characterized by induction of hemocyte recruitment and collagen deposition." Physiological reports 4, 12 (2016): Details. Full text
  • Franklin, BM ;Xiang, L ;Collett, JA ;Rhoads, MK ;Osborn, JL "Open problem-based instruction impacts understanding of physiological concepts differently in undergraduate students." Advances in physiology education 39, 4 (2015): 327-34. Details. Full text
  • Collett, JA ;Hart, AK ;Patterson, E ;Kretzer, J ;Osborn, JL "Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome." Physiological reports 1, 5 (2013): e00104. Details. Full text
  • Osborn, JL ;Sacks, R. "Chapter 2: Nasal obstruction." American journal of rhinology & allergy 27, 3 (2013): 7-8. Details. Full text
  • Stocker, SD ;Osborn, JL ;Carmichael, SP "Forebrain osmotic regulation of the sympathetic nervous system." Clinical and experimental pharmacology & physiology 35, 5-6 (2008): 695-700. Details. Full text
  • Basile, DP ;Donohoe, D.;Roethe, K.;Osborn, JL "Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function." American journal of physiology. Renal physiology 281, 5 (2001): F887-99. Details. Full text
  • Camara, AK ;Osborn, JL "Alpha-adrenergic systems mediate chronic central AII hypertension in rats fed high sodium chloride diet from weaning." Journal of the autonomic nervous system 76, 1 (1999): 28-34. Details. Full text
  • Camara, AK ;Osborn, JL "AT1 receptors mediate chronic central nervous system AII hypertension in rats fed high sodium chloride diet from weaning." Journal of the autonomic nervous system 72, 1 (1998): 16-23. Details. Full text
  • Osborn, JL ;Camara, AK "Renal neurogenic mediation of intracerebroventricular angiotensin II hypertension in rats raised on high sodium chloride diet." Hypertension (Dallas, Tex. : 1979) 30, 3 Pt 1 (1997): 331-6. Details.
  • Osborn, JL ;Plato, CF ;Gordin, E.;He, XR "Long-term increases in renal sympathetic nerve activity and hypertension." Clinical and experimental pharmacology & physiology 24, 1 (1997): 72-6. Details. Full text
  • Plato, CF ;Osborn, JL "Chronic renal neuroadrenergic hypertension is associated with increased renal norepinephrine sensitivity and volume contraction." Hypertension (Dallas, Tex. : 1979) 28, 6 (1996): 1034-40. Details.
  • Johnson, CP ;Sarna, SK ;Cowles, VE ;Osborn, JL ;Zhu, YR ;Bonham, L.;Buchmann, E.;Baytiyeh, R.;Telford, GL ;Roza, AM "Motor activity and transit in the autonomically denervated jejunum." American journal of surgery 167, 1 (1994): 80-8. Details. Full text
  • Greenberg, S.;Osborn, JL "Relationship between sodium balance and renal innervation during hypertension development in the spontaneously hypertensive rat." Journal of hypertension 12, 12 (1994): 1359-64. Details.
  • Lindsay, BD ;Chung, MK ;Gamache, MC ;Luke, RA ;Schechtman, KB ;Osborn, JL ;Cain, ME "Therapeutic end points for the treatment of atrioventricular node reentrant tachycardia by catheter-guided radiofrequency current." Journal of the American College of Cardiology 22, 3 (1993): 733-40. Details. Full text
  • Nelson, LD ;Osborn, JL "Role of intrarenal ANG II in reflex neural stimulation of plasma renin activity and renal sodium reabsorption." The American journal of physiology 265, 2 Pt 2 (1993): R392-8. Details. Full text
  • Prager, NA ;Cox, JL ;Lindsay, BD ;Ferguson TB, Jr ;Osborn, JL ;Cain, ME "Long-term effectiveness of surgical treatment of ectopic atrial tachycardia." Journal of the American College of Cardiology 22, 1 (1993): 85-92. Details. Full text
  • Greenberg, SG ;Enders, C.;Osborn, JL "Renal nerves affect rate of achieving sodium balance in spontaneously hypertensive rats." Hypertension (Dallas, Tex. : 1979) 22, 1 (1993): 1-8. Details.
  • Nelson, LD ;Osborn, JL "Neurogenic control of renal function in response to graded nonhypotensive hemorrhage in conscious dogs." The American journal of physiology 264, 4 Pt 2 (1993): R661-7. Details. Full text
  • Lindsay, BD ;Osborn, JL ;Schechtman, KB ;Kenzora, JL ;Ambos, HD ;Cain, ME "Prospective detection of vulnerability to sustained ventricular tachycardia in patients awaiting cardiac transplantation." The American journal of cardiology 69, 6 (1992): 619-24. Details. Full text
  • Osborn, JL "Relation between sodium intake, renal function, and the regulation of arterial pressure." Hypertension (Dallas, Tex. : 1979) 17, 1 Suppl (1991): I91-6. Details.
  • Dawson, CA ;Cowley AW, Jr ;Spurr, GB ;Osborn, JL ;Raff, H.;Forster, HV ;Harder, DR ;Liard, JF ;Lombard, JH ;Stekiel, WJ "Performance on multiple choice/short answer tests is not a sufficient criterion for evaluating the educational value of live animal laboratories in the teaching of physiology." The American journal of physiology 261, 6 Pt 3 (1991): S34-5. Details. Full text
  • Greenberg, SG ;Tershner, S.;Osborn, JL "Neurogenic regulation of rate of achieving sodium balance after increasing sodium intake." The American journal of physiology 261, 2 Pt 2 (1991): F300-7. Details. Full text
  • Lombard, JH ;Eskinder, H.;Kauser, K.;Osborn, JL ;Harder, DR "Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure." The American journal of physiology 259, 1 Pt 2 (1990): H29-33. Details. Full text
  • Marsh, DJ ;Osborn, JL ;Cowley AW, Jr "1/f fluctuations in arterial pressure and regulation of renal blood flow in dogs." The American journal of physiology 258, 5 Pt 2 (1990): F1394-400. Details. Full text
  • Uda, M.;Osborn, JL ;Lee, CK ;Nakhleh, RE ;Song, CW "Pathophysiological changes after local heating of rat liver." International journal of radiation oncology, biology, physics 18, 3 (1990): 587-94. Details. Full text
  • Osborn, JL ;Curro, TG "Renal sympathetic nerve activity and arterial pressure responses to changes in postural position of conscious dogs." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 192, 3 (1989): 248-54. Details.
  • O'Hair, DP ;Adams, MB ;Tunberg, TC ;Osborn, JL "Relationships among endotoxemia, arterial pressure, and renal function in dogs." Circulatory shock 27, 3 (1989): 199-210. Details.
  • Osborn, JL ;Harland, RW "Alpha 1-adrenoceptor mediation of urinary bicarbonate excretion." The American journal of physiology 255, 6 Pt 2 (1988): F1116-21. Details. Full text
  • Osborn, JL ;Roman, RJ ;Ewens, JD "Renal nerves and the development of Dahl salt-sensitive hypertension." Hypertension (Dallas, Tex. : 1979) 11, 6 Pt 1 (1988): 523-8. Details.
  • Roman, RJ ;Osborn, JL "Renal function and sodium balance in conscious Dahl S and R rats." The American journal of physiology 252, 5 Pt 2 (1987): R833-41. Details. Full text
  • Osborn, JL ;Kinstetter, DD "Effects of altered NaCl intake on renal hemodynamic and renin release responses to RNS." The American journal of physiology 253, 5 Pt 2 (1987): F976-81. Details. Full text
  • Cowley AW, Jr ;Barber, WJ ;Lombard, JH ;Osborn, JL ;Liard, JF "Relationship between body fluid volumes and arterial pressure." Federation proceedings 45, 13 (1986): 2864-70. Details.
  • Osborn, JL ;Lawton, MT "Neurogenic antinatriuresis during development of acute cardiac tamponade." The American journal of physiology 250, 2 Pt 2 (1986): H195-201. Details. Full text
  • Osborn, JL ;Roman, RJ ;Harland, RW "Mechanisms of antinatriuresis during low-frequency renal nerve stimulation in anesthetized dogs." The American journal of physiology 249, 3 Pt 2 (1985): R360-7. Details. Full text
  • Osborn, JL ;Kopp, UC ;Thames, MD ;DiBona, GF "Interactions among renal nerves, prostaglandins, and renal arterial pressure in the regulation of renin release." The American journal of physiology 247, 5 Pt 2 (1984): F706-13. Details. Full text
  • Seagard, JL ;Hopp, FA ;Bosnjak, ZJ ;Osborn, JL ;Kampine, JP "Sympathetic efferent nerve activity in conscious and isoflurane-anesthetized dogs." Anesthesiology 61, 3 (1984): 266-70. Details. Full text
  • Osborn, JL ;Hoversten, LG ;DiBona, GF "Impaired blood flow autoregulation in nonfiltering kidneys: effects of theophylline administration." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 174, 3 (1983): 328-35. Details.
  • Osborn, JL ;Holdaas, H.;Thames, MD ;DiBona, GF "Renal adrenoceptor mediation of antinatriuretic and renin secretion responses to low frequency renal nerve stimulation in the dog." Circulation research 53, 3 (1983): 298-305. Details.
  • Osborn, JL ;Thames, MD ;DiBona, GF "Renal nerves modulate renin secretion during autoregulation." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 169, 4 (1982): 432-7. Details.
  • Osborn, JL ;Thames, MD ;DiBona, GF "Role of macula densa in renal nerve modulation of renin secretion." The American journal of physiology 242, 3 (1982): R367-71. Details. Full text
  • Francisco, LL ;Osborn, JL ;DiBona, GF "Prostaglandin in renin release during sodium deprivation." The American journal of physiology 243, 6 (1982): F537-42. Details. Full text
  • Osborn, JL ;DiBona, GF ;Thames, MD "Role of renal alpha-adrenoceptors mediating renin secretion." The American journal of physiology 242, 6 (1982): F620-6. Details. Full text
  • DiBona, GF ;Johns, EJ ;Osborn, JL "The effect of vagotomy on sodium reabsorption and renin release in anaesthetized dogs subjected to 60 degrees head-up tilt." The Journal of physiology 320, (1981): 293-302. Details. Full text
  • Osborn, JL ;Francisco, LL ;DiBona, GF "Effect of renal nerve stimulation on renal blood flow autoregulation and antinatriuresis during reductions in renal perfusion pressure." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 168, 1 (1981): 77-81. Details.
  • Osborn, JL ;Kopp, UC ;DiBona, GF "Ischemic acute renal failure: newer implications of stopped pipes." The Journal of laboratory and clinical medicine 98, 1 (1981): 16-20. Details.
  • Osborn, JL ;DiBona, GF ;Thames, MD "Beta-1 receptor mediation of renin secretion elicited by low-frequency renal nerve stimulation." The Journal of pharmacology and experimental therapeutics 216, 2 (1981): 265-9. Details. Full text
  • Wallace, KB ;Osborn, JL ;Bailie, MD "Species differences in the kinetics of the renin-substrate reaction in plasma." Journal of pharmacological methods 4, 2 (1980): 141-54. Details. Full text
  • Osborn, JL ;Hook, JB ;Bailie, MD "Effect of saralasin and indomethacin on renal function in developing piglets." The American journal of physiology 238, 5 (1980): R438-42. Details. Full text
  • Osborn, JL ;Noordewier, B.;Hook, JB ;Bailie, MD "Mechanism of prostaglandin E(2) stimulation of renin secretion." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 159, 2 (1978): 249-52. Details.
  • Osborn, JL ;Hook, JB ;Bailie, MD "Control of renin release. Effects of d-propranolol and renal denervation on furosemide-induced renin release in the dog." Circulation research 41, 4 (1977): 481-6. Details.
  • Hook, JB ;Cardona, R.;Osborn, JL ;Bailie, MD ;Gehring, PJ "The renal handling of 2,4,5-trichlorophenoxy- acetic acid (2,4,5-T) in the dog." Food and cosmetics toxicology 14, 1 (1976): 19-23. Details.
  • Swart, GL ;Mateer, JR ;DeBehnke, DJ ;Jameson, SJ ;Osborn, JL "The effect of compression duration on hemodynamics during mechanical high-impulse CPR." Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1, 5 (1969): 430-7. Details. Full text
  • Singleton, J ;Osborn, JL ;Lillis, L ;Hawkins, K ;Guelig, D ;Price, W ;Johns, R ;Ebels, K ;Boyle, D ;Weigl, B ;LaBarre, P "Electricity-free amplification and detection for molecular point-of-care diagnosis of HIV-1." PloS one 9, 11 (0): e113693. Details. Full text
  • Collett, JA ;Paulose, JK ;Cassone, VM ;Osborn, JL "Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat." PloS one 10, 8 (0): e0136441. Details. Full text
  • Osborn, JL ;Johns, EJ "Renal neurogenic control of renin and prostaglandin release." Mineral and electrolyte metabolism 15, 1-2 (0): 51-8. Details.
  • Osborn, JL ;Hook, JB ;Bailie, MD "Regulation of plasma renin in developing piglets." Developmental pharmacology and therapeutics 1, 4 (0): 217-28. Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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