S. Randal Voss

  • Professor
  • Associate Faculty, Spinal Cord and Brain Injury Research Center
  • Director, Ambystoma Genetic Stock Center
  • Bioinformatics and Computational Biology
  • Biology
  • Biology Education
  • Cell and Developmental Biology
  • Ecology and Evolutionary Biology
  • Genetics and Genomics
  • Neuroscience and Neurobiology
  • Pharmacology Toxicology and Environmental Health
  • Physiology
THM 211
(859) 257-9888

BS Francis Marion College 1986
MS Western Carolina University 1988
Ph.D. Clemson University 1994
Post Doc University of California, Davis 1994-1998


Salamander Genome Project: Salamanders are important vertebrate model organisms in several areas of biomedical research, including tissue regeneration, neural transmission, vision, olfaction, and aging. The Salamander Genome Project is developing genomic resources under National Institute of Health support to better enable research efforts using the Mexican axolotl (Ambystoma mexicanum) and related species. Bioinformatic information from the SGP is made available to the community via a website called Sal-Site (www.ambystoma.org). Current research efforts include mapping mutants and quantitative trait loci, developing a 3x Bacterial Artificial Chromosome (BAC) library, and innovating whole-chromosome isolation and sequencing approaches, with additional support from the Army Research Office to characterize the large, axolotl genome.  

Salamander Regenerome Project: Salamanders are unparalleled in their ability to regenerate complex body parts, including limbs and spinal cord. The Salamander Regenerome Project is funded by a Multidisciplinary University Research Initiative grant from the Department of Defense, and involves collaborators from Tulane University (Ken Muneoka) and University of California, Irvine (Drs David Gardiner and Sue Bryant). Current research efforts include development of gene expression databases and network models of limb regeneration. Also genetic approaches are being used to identify quantitative trait loci that explain variation in regeneration rate.

Salamander Metamorphosis and Paedomorphosis: Salamanders are one of three primary groups of amphibians, the other two being caecilians and anurans. Ancestrally, all three groups trace their origins to ancestors that present complex life cycles with an aquatic larval phase and more terrestrial adult phase. However, alternate modes of development subsequently evolved within all three groups.  Interestingly, ancestral vestiges of metamorphosis are observed during early development of direct developing anurans and salamanders, suggesting shared evolutionary potential for radical and early shifts in the timing of metamorphosis. Radical, later shifts in metamorphic timing are only observed in salamanders.  In the most extreme cases, metamorphosis has been abolished completely, yielding bizarre larval-form adults with completely aquatic life cycles. These unique paedomorphic forms are ideal for investigating mechanisms of thyroid hormone regulation that are associated with adaptive delays in metamorphic timing and the evolution of novel life histories. 


PubMed Publications*: 
  • Nguyen, M ;Singhal, P ;Piet, JW ;Shefelbine, SJ ;Maden, M.;Voss, SR ;Monaghan, JR "Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl." Development (Cambridge, England) 144, 4 (2017): 601-611. Details. Full text
  • Franklin, BM ;Voss, SR ;Osborn, JL "Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration." Mechanisms of development 146, (2017): 42-54. Details. Full text
  • Wang, X.;Zhang, Y.;Ponomareva, LV ;Qiu, Q ;Woodcock, R ;Elshahawi, SI ;Chen, X.;Zhou, Z.;Hatcher, BE ;Hower, JC ;Zhan, CG ;Parkin, S.;Kharel, MK ;Voss, SR ;Shaaban, KA ;Thorson, JS "Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe." Angewandte Chemie (International ed. in English) 56, 11 (2017): 2994-2998. Details. Full text
  • Hime, PM ;Hotaling, S ;Grewelle, RE ;O'Neill, EM ;Voss, SR ;Shaffer, HB ;Weisrock, DW "The influence of locus number and information content on species delimitation: an empirical test case in an endangered Mexican salamander." Molecular ecology 25, 23 (2016): 5959-5974. Details. Full text
  • Ponomareva, LV ;Athippozhy, A.;Thorson, JS ;Voss, SR "Using Ambystoma mexicanum (Mexican axolotl) embryos, chemical genetics, and microarray analysis to identify signaling pathways associated with tissue regeneration." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 178, (2015): 128-35. Details.
  • Voss, SR ;Palumbo, A ;Nagarajan, R ;Gardiner, DM ;Muneoka, K ;Stromberg, AJ ;Athippozhy, AT "Gene expression during the first 28 days of axolotl limb regeneration I: Experimental design and global analysis of gene expression." Regeneration (Oxford, England) 2, 3 (2015): 120-136. Details.
  • McCusker, CD ;Athippozhy, A.;Diaz-Castillo, C ;Fowlkes, C ;Gardiner, DM ;Voss, SR "Positional plasticity in regenerating Amybstoma mexicanum limbs is associated with cell proliferation and pathways of cellular differentiation." BMC developmental biology 15, (2015): 45. Details. Full text
  • Athippozhy, A.;Lehrberg, J ;Monaghan, JR ;Gardiner, DM ;Voss, SR "Characterization of <i>in vitro</i> transcriptional responses of dorsal root ganglia cultured in the presence and absence of blastema cells from regenerating salamander limbs." Regeneration (Oxford, England) 1, 2 (2014): 1-10. Details.
  • Sousounis, K ;Athippozhy, AT ;Voss, SR ;Tsonis, PA "Plasticity for axolotl lens regeneration is associated with age-related changes in gene expression." Regeneration (Oxford, England) 1, 3 (2014): 47-57. Details.
  • Thompson, S ;Muzinic, L ;Muzinic, C ;Niemiller, ML ;Voss, SR "Probability of Regenerating a Normal Limb After Bite Injury in the Mexican Axolotl (<i>Ambystoma mexicanum</i>)." Regeneration (Oxford, England) 1, 3 (2014): 27-32. Details.
  • Hui, SP ;Monaghan, JR ;Voss, SR ;Ghosh, S. "Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord." Developmental dynamics : an official publication of the American Association of Anatomists 242, 7 (2013): 847-60. Details. Full text
  • Zhu, W.;Kuo, D.;Nathanson, J.;Satoh, A.;Pao, GM ;Yeo, GW ;Bryant, SV ;Voss, SR ;Gardiner, DM ;Hunter, T. "Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration." Development, growth & differentiation 54, 7 (2012): 673-85. Details. Full text
  • Voss, SR ;Kump, DK ;Walker, JA ;Shaffer, HB ;Voss, GJ "Thyroid hormone responsive QTL and the evolution of paedomorphic salamanders." Heredity 109, 5 (2012): 293-8. Details. Full text
  • Cosden, RS ;Lattermann, C.;Romine, S.;Gao, J.;Voss, SR ;MacLeod, JN "Intrinsic repair of full-thickness articular cartilage defects in the axolotl salamander." Osteoarthritis and cartilage 19, 2 (2011): 200-5. Details. Full text
  • Dixon, JE ;Allegrucci, C.;Redwood, C.;Kump, K.;Bian, Y.;Chatfield, J.;Chen, YH ;Sottile, V.;Voss, SR ;Alberio, R.;Johnson, AD "Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammals." Development (Cambridge, England) 137, 18 (2010): 2973-80. Details. Full text
  • Fitzpatrick, BM ;Johnson, JR ;Kump, DK ;Smith, JJ ;Voss, SR ;Shaffer, HB "Rapid spread of invasive genes into a threatened native species." Proceedings of the National Academy of Sciences of the United States of America 107, 8 (2010): 3606-10. Details. Full text
  • Sharanowski, BJ ;Robbertse, B.;Walker, J.;Voss, SR ;Yoder, R.;Spatafora, J.;Sharkey, MJ "Expressed sequence tags reveal Proctotrupomorpha (minus Chalcidoidea) as sister to Aculeata (Hymenoptera: Insecta)." Molecular phylogenetics and evolution 57, 1 (2010): 101-12. Details. Full text
  • Voss, SR ;Epperlein, HH ;Tanaka, EM "Ambystoma mexicanum, the axolotl: a versatile amphibian model for regeneration, development, and evolution studies." Cold Spring Harbor protocols 2009, 8 (2009): pdb.emo128. Details. Full text
  • Rao, N.;Jhamb, D.;Milner, DJ ;Li, B.;Song, F.;Wang, M.;Voss, SR ;Palakal, M.;King, MW ;Saranjami, B.;Nye, HL ;Cameron, JA ;Stocum, DL "Proteomic analysis of blastema formation in regenerating axolotl limbs." BMC biology 7, (2009): 83. Details. Full text
  • Page, RB ;Monaghan, JR ;Walker, JA ;Voss, SR "A model of transcriptional and morphological changes during thyroid hormone-induced metamorphosis of the axolotl." General and comparative endocrinology 162, 2 (2009): 219-32. Details. Full text
  • Page, RB ;Voss, SR "Induction of metamorphosis in axolotls (Ambystoma mexicanum)." Cold Spring Harbor protocols 2009, 8 (2009): pdb.prot5268. Details. Full text
  • Fitzpatrick, BM ;Johnson, JR ;Kump, DK ;Shaffer, HB ;Smith, JJ ;Voss, SR "Rapid fixation of non-native alleles revealed by genome-wide SNP analysis of hybrid tiger salamanders." BMC evolutionary biology 9, (2009): 176. Details. Full text
  • Monaghan, JR ;Epp, LG ;Putta, S.;Page, RB ;Walker, JA ;Beachy, CK ;Zhu, W.;Pao, GM ;Verma, IM ;Hunter, T.;Bryant, SV ;Gardiner, DM ;Harkins, TT ;Voss, SR "Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration." BMC biology 7, (2009): 1. Details. Full text
  • Cotter, JD ;Storfer, A.;Page, RB ;Beachy, CK ;Voss, SR "Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection." BMC genomics 9, (2008): 493. Details. Full text
  • Theodosiou, M.;Monaghan, JR ;Spencer, ML ;Voss, SR ;Noonan, DJ "Isolation and characterization of axolotl NPDC-1 and its effects on retinoic acid receptor signaling." Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 147, 2 (2007): 260-70. Details. Full text
  • Monaghan, JR ;Walker, JA ;Page, RB ;Putta, S.;Beachy, CK ;Voss, SR "Early gene expression during natural spinal cord regeneration in the salamander Ambystoma mexicanum." Journal of neurochemistry 101, 1 (2007): 27-40. Details. Full text
  • Jones, MT ;Voss, SR ;Ptacek, MB ;Weisrock, DW ;Tonkyn, DW "River drainages and phylogeography: an evolutionary significant lineage of shovel-nosed salamander (Desmognathus marmoratus) in the southern Appalachians." Molecular phylogenetics and evolution 38, 1 (2006): 280-7. Details. Full text
  • Weisrock, DW ;Shaffer, HB ;Storz, BL ;Storz, SR ;Voss, SR "Multiple nuclear gene sequences identify phylogenetic species boundaries in the rapidly radiating clade of Mexican ambystomatid salamanders." Molecular ecology 15, 9 (2006): 2489-503. Details. Full text
  • Shaffer, HB ;Fellers, GM ;Voss, SR ;Oliver, JC ;Pauly, GB "Species boundaries, phylogeography and conservation genetics of the red-legged frog (Rana aurora/draytonii) complex." Molecular ecology 13, 9 (2004): 2667-77. Details. Full text
  • Voss, SR ;Prudic, KL ;Oliver, JC ;Shaffer, HB "Candidate gene analysis of metamorphic timing in ambystomatid salamanders." Molecular ecology 12, 5 (2003): 1217-23. Details. Full text
  • Voss, SR ;Smith, JJ ;Gardiner, DM ;Parichy, DM "Conserved vertebrate chromosome segments in the large salamander genome." Genetics 158, 2 (2001): 735-46. Details. Full text
  • Voss, SR ;Shaffer, HB ;Taylor, J.;Safi, R.;Laudet, V. "Candidate gene analysis of thyroid hormone receptors in metamorphosing vs. nonmetamorphosing salamanders." Heredity 85 ( Pt 2), (2000): 107-14. Details.
  • Shaffer, HB ;Fellers, GM ;Magee, A.;Voss, SR "The genetics of amphibian declines: population substructure and molecular differentiation in the yosemite toad, Bufo canorus (Anura, bufonidae) based on single-strand conformation polymorphism analysis (SSCP) and mitochondrial DNA sequence data." Molecular ecology 9, 3 (2000): 245-57. Details. Full text
  • Voss, SR ;Shaffer, HB "Evolutionary genetics of metamorphic failure using wild-caught vs. laboratory axolotls (Ambystoma mexicanum)." Molecular ecology 9, 9 (2000): 1401-7. Details. Full text
  • Parichy, DM ;Stigson, M.;Voss, SR "Genetic analysis of steel and the PG-M/versican-encoding gene AxPG as candidates for the white (d) pigmentation mutant in the salamander Ambystoma mexicanum." Development genes and evolution 209, 6 (1999): 349-56. Details.
  • Voss, SR ;Shaffer, HB "Adaptive evolution via a major gene effect: paedomorphosis in the Mexican axolotl." Proceedings of the National Academy of Sciences of the United States of America 94, 25 (1997): 14185-9. Details. Full text
  • Voss, SR ;Shaffer, HB "What insights into the developmental traits of urodeles does the study of interspecific hybrids provide?" The International journal of developmental biology 40, 4 (1996): 885-93. Details. Full text
  • Page, RB ;Boley, MA ;Kump, DK ;Voss, SR "Genomics of a metamorphic timing QTL: met1 maps to a unique genomic position and regulates morph and species-specific patterns of brain transcription." Genome biology and evolution 5, 9 (0): 1716-30. Details. Full text
  • Voss, SR ;Athippozhy, A.;Woodcock, MR "Transcriptomics using axolotls." Methods in molecular biology (Clifton, N.J.) 1290, (0): 309-19. Details. Full text
  • Voss, GJ ;Kump, DK ;Walker, JA ;Voss, SR "Variation in salamander tail regeneration is associated with genetic factors that determine tail morphology." PloS one 8, 7 (0): e67274. Details. Full text
  • Baddar, NW ;Woodcock, MR ;Khatri, S ;Kump, DK ;Voss, SR "Sal-Site: research resources for the Mexican axolotl." Methods in molecular biology (Clifton, N.J.) 1290, (0): 321-36. Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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