Validation of a closed-loop sensory stimulation technique for selective sleep restriction in mice.

TitleValidation of a closed-loop sensory stimulation technique for selective sleep restriction in mice.
Publication TypeJournal Article
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Volume2014
Pagination3771-4
Date Published2014
ISSN1557-170X
Abstract

Experimental manipulation of sleep in rodents is an important tool for analyzing the mechanisms of sleep and related disorders in humans. Sleep restriction systems have relied in the past on manual sensory stimulation and recently on more sophisticated automated means of delivering the same. The ability to monitor and track behavior through the electroencephalogram (EEG) and other modalities provides the opportunity to implement more selective sleep restriction that is targeted at particular stages of sleep with flexible control over their amount, duration, and timing. In this paper we characterize the performance of a novel tactile stimulation system operating in closed-loop to interrupt rapid eye movement (REM) sleep in mice when it is detected in real time from the EEG. Acute experiments in four wild-type mice over six hours showed that a reduction of over 50% of REM sleep was feasible without affecting non-REM (NREM) sleep. The animals remained responsive to the stimulus over the six hour duration of the experiment.

URLhttps://dx.doi.org/10.1109/EMBC.2014.6944444
DOI10.1109/EMBC.2014.6944444
Short TitleConf Proc IEEE Eng Med Biol Soc
X
Enter your linkblue username.
Enter your linkblue password.
Secure Login

This login is SSL protected

Loading