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See UK NOW News about the NEW Kentucky Chapter of the American Physiological Society (APS). http://uknow.uky.edu/node/25964
Synaptic Transmission and Neuromodulation
My primary research interest is to understand the detailed mechanisms of synaptic differentiation among neurons and those mechanisms employed between neurons and muscle cells. The nerve cell is chemically integrated with other cells at morphologically-identified locations called synapses. The characteristics of the synapse are affected by its activity level which modulates long-term alterations in both synaptic structure and performance. Neuromodulators that are endogenously released either enhance or suppress synaptic efficacy, in turn affecting the behavioral state of an animal. Neuromodulators affect cellular process by various intracellular messenger cascades that are dependent on the type of neuromodulator and its associated receptor. Such changes are believed to play a role in learning and memory, as well as in the behavioral state of an animal.
1. 2014 to 2015. Kentucky Department of Education. MUSE - modeling for understanding in science and engineering. Middle School. Proposal provides an opportunity to improve student learning in science and create exemplars of middle school multi-disciplinary units of study aligned to NGSS with integrated engineering core ideas focused on Global Climate and human health-related issues.$75,000 PI. is Kimberly Zeidler-Watters, Partnership Inst. for Math and Science. CO-PI Robin Cooper
2. Toyota PEP Grant with Fayette County Public Schools (FCPS) 2014- 2015. Title: “Fayette County Public Schools District Professional Development Plan.” Mr. David Helm, Science coordinator for FCPS is the PI’s on the grant). $ 14,000.
3. January 2014 to June 2015. Kentucky Department of Education. MUSE - modeling for understanding in science and engineering. High School. Year 12 Improving Educator Quality. $130,000. The second year renewal, if approved, will run from January 2015 to June 2016. PI. is Kimberly Zeidler-Watters, Partnership Inst. for Math and Science. CO-PI Robin Cooper.
4. 2013. Kentucky Department of Education. MUSE - modeling for understanding in science and engineering. Kentucky’s Mathematics and Science Partnership (MSP) 2013. Kentucky Department of Education $140,000 for year 1 (January, 2013 to September 30, 2013) and at $195,000 for the second year (October 1, 2013 to September 30, 2014), with a possible third year (at $97,500). PI. is Kimberly Zeidler-Watters, Partnership Inst. for Math and Science. CO-PI Robin Cooper.
5. KY Department of Education. Start 10/01/12 End 09/30/13. Science Leadership Support Network - Central Region Year 3. # 3048109915. PI. is Kimberly Zeidler-Watters, Partnership Inst. for Math and Science. CO-PI Robin Cooper. Total $97,500.
6. KY Department of Education. Start 10/01/12 End 09/30/13. Science Leadership Support Network – Eastern Region Year 3. # 3048109914. PI. is Kimberly Zeidler-Watters, Partnership Inst. for Math and Science. Only one CO-PI Robin Cooper. Total $97,500.
2007-2012. CHIEF EDITOR for International Journal of Zoological Research
2013- present. A member of JoVE's Editorial Board in the Neurosciences. (http://www.jove.com/editorial-boards). Please see the web page for more about this wonderful journal. http://www.jove.com/about Journal of Visualized Experiments (JoVE) is a peer reviewed, PubMed indexed journal devoted to the publication of biological, medical, chemical and physical research in a video format.
106. Wu, W.-H. and Cooper, R.L. (2012) The regulation and packaging of synaptic vesicles as related to recruitment within glutamatergic synapses. Neuroscience 225:185–198.
107. Wu, W.-H. and Cooper, R.L. (2012) Role of serotonin in the regulation of synaptic transmission in invertebrate NMJs. Experimental Neurobiology 21(3):101-112.
108. Holsinger, R.C., and Cooper, R.L. (2012). Effect of Environment and Modulators on Hindgut and Heart Function in Invertebrates: Crustaceans and Drosophila. Tested Studies for Laboratory Teaching, Volume 33 (K. McMahon, Editor). Proceedings of the 33rd Conference of the Association for Biology Laboratory Education (ABLE), 366 pages.http://www.ableweb.org/volumes/vol-33/v33reprint.php?ch=7
109. Chung,Y-S. Cooper, R.M., Graff, J. and Cooper, R.L. (2012) The acute and chronic effect of low temperature on survival, heart rate and neural function in crayfish (Procambarus clarkii) and prawn (Macrobrachium rosenbergii) species. Open Journal of Molecular and Integrative Physiology 2:75-86.
110. Bierbower, S.M., Shuranova, Z. P., Viele, K. and Cooper, R.L. (2013) Comparative study of environmental factors influencing motor task learning and memory retention in sighted and blind crayfish. Brain and Behavior 3 (1) 4-13.
111. Becnel, J., Johnson, O., Majeed, Z.R., Tran, V., Yu, B., Roth, B.L., Cooper, R.L., Kerut, E.K., Nichols, C.D. (2013) DREADDs in Drosophila: A Pharmacogenetic Approach for Controlling Behavior, Neuronal Signaling, and Physiology in the Fly. Cell Reports 4(5):1049-59. doi: 10.1016/j.celrep.2013.08.003.
112. Wu, W.-H. and Cooper, R.L. (2013) Physiological separation of vesicle pools in low- and high-output nerve terminals. Neuroscience Research 75: 275–282. (5 yr impact factor 2.376). pubmed click link
113. Bierbower, S.M. and Cooper, R.L. (2013) The mechanistic action of carbon dioxide on a neural circuit and NMJ communication. Journal of Experimental Zoology 319A:340–354. http://onlinelibrary.wiley.com/doi/10.1002/jez.1798/full
114. Bierbower, S.M., Nadolski, J. and Cooper, R.L. (2013) Sensory systems and environmental change on behavior during social interactions. International Journal of Zoology. Vol: 2013, Article ID 573802, 16 pages http://dx.doi.org/10.1155/2013/573802
115. Titlow, J., Majeed, Z.R., Hartman, H.B., Burns, E., and Cooper, R.L. (2013) Neural Circuit Recording from an Intact Cockroach Nervous System. Journal of Visualized Experiments (JoVE). (81), e50584, doi:10.3791/50584 (2013). Professional movie and peer reviewed manuscript. http://www.jove.com/video/50584/neural-circuit-recording-from-an-intact-cockroach-nervous-system
116. Titlow, J., Majeed, Z.R., Nicholls, J.G. and Cooper, R.L. (2013) Identifiable neurons in the central nervous system of a leech via electrophysiology and morphology, sensory field maps in skin and synapse formation in culture: Student laboratory exercises. Journal of Visualized Experiments (JoVE). (81), e50631, doi:10.3791/50631 Professional movie and peer reviewed manuscript. http://www.jove.com/video/50631/intracellular-recording-sensory-field-mapping-culturing-identified
117. Majeed, Z.R., Titlow, J., Hartman, H.B. and Cooper, R.L. (2013) Proprioception and tension receptors in crab limbs: Student laboratory exercises. Journal of Visualized Experiments (JoVE). (80), e51050, doi:10.3791/51050 Professional movie and peer reviewed manuscript. http://www.jove.com/video/51050/proprioception-tension-receptors-crab-limbs-student-laboratory
118. Titlow, J.S., Rufer, J., King, K., and Cooper, R.L. (2013) Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart. Physiological Reports. 1 (2), 2013, e00020, doi:10.1002/phy2.20 http://web.as.uky.edu/Biology/faculty/cooper/labWWW-PDFs/Josh-Physiological%20report2013.pdf
119. Cooper, A.-S., Johnstone, A.F.M. and Cooper, R.L. (2013) Motor nerve terminal morphology with unloading and reloading of muscle. Journal of Crustacean Biology.33(6): 818-827.
120. Majeed, Z.R., Nichols, C.D., and Cooper, R.L. (2013) 5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics. Journal of Applied Physiology 15: 1656-1665, 5 yr impact factor 4.156.
121. deCastro, C., Titlow, J., Majeed, Z.R., and Cooper, R.L. (2014) Examining the usefulness of various salines by physiological assays designed for larval Drosophila melanogaster: heart rate, synaptic transmission at neuromuscular junction and central circuits in the CNS. Journal of Comparative Physiology A. 200:83-92.
122. Majeed, Z.R., Stacy, A., and Cooper, R.L. (2014) Pharmacological identification of serotonin receptor subtypes on Drosophila larval heart. Journal of Comparative Physiology B.184(2):205-219. Impact factor 2.024.
123. Titlow, J.S., Rice, J., Majeed, Z.R., Holsopple, E., Biecker, S., and Cooper, R.L. (2014) Anatomical and genotype-specific mechanosensory responses in Drosophila melanogaster larvae. (In Press, Neuroscience Research) Impact factor 2.249
124. Titlow, J.S., Anderson H. and Cooper, R.L. (2014). Lights and Larvae: Using optogenetics to teach recombinant DNA and neurobiology. (In Review)
125. Titlow, J.S., Biecker, S. and Cooper, R.L. (2014). Mechanosensory habituation in Drosophila melanogaster larvae. (In Review).