A decrease of ATP production steered by PEDF in cardiomyocytes with oxygen-glucose deprivation is associated with an AMPK-dependent degradation pathway.
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| Abstract | :
The activated AMP activated protein kinase (AMPK) serves as a transient protective cardiovascular kinase via preserving adenosine triphosphate (ATP) production under ischemic conditions. However, recent studies reveal that inhibition of AMPK in stroke is neuroprotection. Pigment epithelium derived factor (PEDF) is also known for the protection of ischemic cardiomyocytes. However, the relationship between PEDF and AMPK in cardiomyocytes is poorly understood. |
| Year of Publication | :
2018
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| Journal | :
International journal of cardiology
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| Date Published | :
2018
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| ISSN Number | :
0167-5273
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| URL | :
http://linkinghub.elsevier.com/retrieve/pii/S0167-5273(17)37784-7
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| DOI | :
10.1016/j.ijcard.2018.01.034
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| Short Title | :
Int J Cardiol
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