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Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients.

Author
Abstract
:

With the advent of multi-gene panel testing for breast cancer patients, germline mutations with unknown association with cancer risk, known as variants of uncertain significance (VUS), are being increasingly identified. Some studies have shown higher rates of contralateral prophylactic mastectomies (CPM) in these patients despite lack of evidence to support this intervention. We analyzed surgical choices in patients who were identified to have VUS.

Year of Publication
:
2018
Journal
:
Journal of the American College of Surgeons
Date Published
:
2018
ISSN Number
:
1072-7515
URL
:
http://linkinghub.elsevier.com/retrieve/pii/S1072-7515(18)30018-8
DOI
:
10.1016/j.jamcollsurg.2017.12.037
Short Title
:
J Am Coll Surg
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