Skip to main content

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.

Author
Abstract
:

We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2 ) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG).

Year of Publication
:
2018
Journal
:
Epilepsia
Date Published
:
2018
ISSN Number
:
0013-9580
URL
:
http://dx.doi.org/10.1111/epi.14005
DOI
:
10.1111/epi.14005
Short Title
:
Epilepsia
Download citation