Considerations for skin carcinogenesis experiments using inducible transgenic mouse models.
| Author | |
|---|---|
| Abstract | :
This study was designed to estimate the percentage of non-malignant skin tumours (papillomas) progressing to malignant squamous cell carcinomas (SCCs) in a carcinogenesis study using established transgenic mouse models. In our skin cancer model, we conditionally induced oncogenic point mutant alleles of p53 and k-ras in undifferentiated, basal cells of the epidermis. |
| Year of Publication | :
2018
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| Journal | :
BMC research notes
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| Volume | :
11
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| Issue | :
1
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| Number of Pages | :
67
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| Date Published | :
2018
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| URL | :
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3182-3
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| DOI | :
10.1186/s13104-018-3182-3
|
| Short Title | :
BMC Res Notes
|
| Download citation |