Lower pre-ART intra-participant HIV-1 pol diversity may not be associated with virologic failure in adults.
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Abstract | :
Identifying pre-ART factors associated with the emergence of HIV-1 drug resistance is critical for optimizing strategies to prevent virologic failure. A previous study reported that lower pre-ART HIV-1 pol diversity was associated with higher risk of virologic failure in HIV-1-infected children. To investigate this association in adults, we measured HIV-1 diversity with deep sequencing in pre-ART samples from adults with well-characterized virologic outcomes in a study (A5142) of initial ART conducted by the AIDS Clinical Trials Group (ACTG). |
Year of Publication | :
0
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Journal | :
PloS one
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Volume | :
13
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Issue | :
1
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Number of Pages | :
e0190438
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Date Published | :
2018
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URL | :
http://dx.plos.org/10.1371/journal.pone.0190438
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DOI | :
10.1371/journal.pone.0190438
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Short Title | :
PLoS One
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