Molecular targeting of cell-permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferation.
| Author | |
|---|---|
| Abstract | :
Chromosome 16 open reading frame 74 (C16orf74) is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and is involved in cancer cell proliferation and invasion through binding to calcineurin (CN). Therefore, C16orf74 is a good target for the development of a PDAC treatment. A cell-permeable dominant-negative (DN) peptide that can inhibit the C16orf74/CN interaction was designed to examine whether this peptide can inhibit PDAC cell proliferation in vitro and in vivo. |
| Year of Publication | :
2017
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| Journal | :
Oncotarget
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| Volume | :
8
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| Issue | :
69
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| Number of Pages | :
113662-113672
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| Date Published | :
2017
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| DOI | :
10.18632/oncotarget.21939
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| Short Title | :
Oncotarget
|
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