Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score.
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| Abstract | :
Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters. |
| Year of Publication | :
2018
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| Journal | :
The lancet. Gastroenterology & hepatology
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| Volume | :
3
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| Issue | :
9
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| Number of Pages | :
626-634
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S2468-1253(18)30163-8
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| DOI | :
10.1016/S2468-1253(18)30163-8
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| Short Title | :
Lancet Gastroenterol Hepatol
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