Copy number polymorphism of glutathione-S-transferase genes (GSTM1 & GSTT1) in susceptibility to lung cancer in a high-risk population from north-east India.
| Author | |
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| Abstract | :
Genetic polymorphisms in glutathione-S-transferase genes ( GSTM1 and GSTT1 ) have been studied intensively for their potential role in lung cancer susceptibility. However, most of the studies on association between the polymorphisms and lung cancer do not distinguish between genotypes with one or two copies of the genes. The present study investigates the gene dosage effects of GSTT1 and GSTM1 copy number and their environmental interactions to examine the association of lung cancer risk with trimodular genotypes of the GSTs in a high-risk population from north-east India. |
| Year of Publication | :
2014
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| Journal | :
The Indian journal of medical research
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| Volume | :
139
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| Issue | :
5
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| Number of Pages | :
720-9
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| ISSN Number | :
0971-5916
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| URL | :
http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=5;spage=720;epage=729;aulast=Ihsan
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| Short Title | :
Indian J Med Res
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