Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.
| Author | |
|---|---|
| Abstract | :
A common feature pharmacophore with two hydrogen-bond acceptor and one aromatic hydrophobic feature has been generated using seven active flavonoids. Docking studies of these compounds well corroborates with the pharmacophore model. Therefore models could be useful for identification of potential novel FAS-II inhibitors. |
| Year of Publication | :
2010
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| Journal | :
Bioorganic & medicinal chemistry letters
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| Volume | :
20
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| Issue | :
16
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| Number of Pages | :
4779-81
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| Date Published | :
2010
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| ISSN Number | :
0960-894X
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(10)00907-8
|
| DOI | :
10.1016/j.bmcl.2010.06.120
|
| Short Title | :
Bioorg Med Chem Lett
|
| Download citation |