Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology.
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Abstract | :
Among the putative mechanisms proposed to be common factors in Down syndrome (DS) and Alzheimer's disease (AD) neuropathology, deficits in protein quality control (PQC) have emerged as a unifying mechanism of neurodegeneration. Considering that disturbance of protein degradation systems is present in DS and that oxidized/misfolded proteins require polyubiquitinylation for degradation via the ubiquitin proteasome system, this study investigated if dysregulation of protein polyubiquitinylation is associated with AD neurodegeneration in DS. |
Year of Publication | :
2017
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Journal | :
Antioxidants & redox signaling
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Volume | :
26
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Issue | :
7
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Number of Pages | :
280-298
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Date Published | :
2017
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ISSN Number | :
1523-0864
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URL | :
https://www.liebertpub.com/doi/10.1089/ars.2016.6686?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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DOI | :
10.1089/ars.2016.6686
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Short Title | :
Antioxid Redox Signal
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