Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation.
| Author | |
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| Abstract | :
The development of ethanol dependence is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis and activation of type II glucocorticoid receptors (GR). These effects may contribute to withdrawal-associated anxiety, craving and relapse to drinking. The present studies examined acute and oral administration of the novel, selective and competitive GR antagonist ORG 34517 on the severity of ethanol withdrawal. |
| Year of Publication | :
2015
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| Journal | :
Drug and alcohol dependence
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| Volume | :
154
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| Number of Pages | :
100-4
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| Date Published | :
2015
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| ISSN Number | :
0376-8716
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| URL | :
https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(15)00317-8
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| DOI | :
10.1016/j.drugalcdep.2015.06.018
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| Short Title | :
Drug Alcohol Depend
|
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