Estradiol up-regulates L-type Ca<sup>2+</sup> channels via membrane-bound estrogen receptor / Phosphoinositide-3kinase / Akt / cAMP response element-binding protein signaling pathway.
| Author | |
|---|---|
| Abstract | :
In long QT type-2 (LQT2), women are more prone to lethal arrhythmias called Torsade de Pointes (TdP) than men. We previously reported that 17-β-estradiol (E2) upregulates L-type Ca2+-channels and current (ICa,L) (∼30%) in rabbit ventricular myocytes by a classical genomic-mechanism mediated by estrogen-receptor-α (ER)α. In LQT2 ( IKr-blockade or bradycardia), the higher Ca2+ influx via ICa,L, causes Ca2+-overload, spontaneous sarcoplasmic reticulum Ca2+-release, and re-activation of ICa,L that trigger early afterdepolarizations (EADs) and TdP. |
| Year of Publication | :
2018
|
| Journal | :
Heart rhythm
|
| Date Published | :
2018
|
| ISSN Number | :
1547-5271
|
| URL | :
http://linkinghub.elsevier.com/retrieve/pii/S1547-5271(18)30019-5
|
| DOI | :
10.1016/j.hrthm.2018.01.019
|
| Short Title | :
Heart Rhythm
|
| Download citation |