Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells.
| Author | |
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| Abstract | :
Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs). |
| Year of Publication | :
2018
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| Journal | :
Stem cell research & therapy
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| Volume | :
9
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| Issue | :
1
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| Number of Pages | :
8
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| Date Published | :
2018
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| URL | :
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0758-0
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| DOI | :
10.1186/s13287-017-0758-0
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| Short Title | :
Stem Cell Res Ther
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