Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling.
| Author | |
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| Abstract | :
Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs for asthma. The present study investigated the involvement of the Notch1 pathway in the anti-inflammatory effect of GCs and its association with Th1/Th2 balance. |
| Year of Publication | :
2018
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| Journal | :
International archives of allergy and immunology
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| Date Published | :
2018
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| ISSN Number | :
1018-2438
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| URL | :
https://www.karger.com?DOI=10.1159/000485890
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| DOI | :
10.1159/000485890
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| Short Title | :
Int Arch Allergy Immunol
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