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The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy.

Author
Abstract
:

Current antiepileptic drugs (AEDs) have several shortcomings. For example, they fail to control seizures in 30% of patients. Hence, there is a need to identify new AEDs. Drug repurposing is the discovery of new indications for approved drugs. This drug "recycling" offers the potential of significant savings in the time and cost of drug development. Many drugs licensed for other indications exhibit antiepileptic efficacy in animal models. Our aim was to create a database of "prescribable" drugs, approved for other conditions, with published evidence of efficacy in animal models of epilepsy, and to collate data that would assist in choosing the most promising candidates for drug repurposing.

Year of Publication
:
2018
Journal
:
Epilepsia
Date Published
:
2018
ISSN Number
:
0013-9580
URL
:
http://dx.doi.org/10.1111/epi.13994
DOI
:
10.1111/epi.13994
Short Title
:
Epilepsia
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