Doug Harrison

  • Associate Professor
  • Director, A&S Imaging Center
  • Biology
  • Cell and Developmental Biology
  • Genetics and Genomics
  • Imaging Center
300 TH Morgan Bldg.
(859) 257-6275
Research Interests:

Ph.D. Johns Hopkins Univ., 1990


Cell Signaling in Development

My primary research interest is in the transduction of developmental signals for cell proliferation and differentiation, specifically focusing on the Janus kinase (JAK) signaling pathway in the fruit fly, Drosophila melanogaster.  In mammals, the JAK pathway is known to transduce signals from such developmentally important molecules as cytokines and growth factors.  Homologues of JAK and other molecules in the pathway have been identified in flies.  My lab is using the extensive genetic and developmental tools available in flies to identify new molecules involved in JAK signaling, define the developmental roles of the pathway in flies, and examine where JAK signaling fits into other developmental pathways.

PubMed Publications*: 
  • Chen, Q.;Giedt, M ;Tang, L.;Harrison, DA "Tools and methods for studying the Drosophila JAK/STAT pathway." Methods (San Diego, Calif.) 68, 1 (2014): 160-72. Details. Full text
  • Wang, L.;Sexton, TR ;Venard, C ;Giedt, M ;Guo, Q.;Chen, Q.;Harrison, DA "Pleiotropy of the Drosophila JAK pathway cytokine Unpaired 3 in development and aging." Developmental biology 395, 2 (2014): 218-31. Details. Full text
  • Harrison, DA "The Jak/STAT pathway." Cold Spring Harbor perspectives in biology 4, 3 (2012): Details. Full text
  • Cai, W.;Rudolph, JL ;Harrison, SM ;Jin, L.;Frantz, AL ;Harrison, DA ;Andres, DA "An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance." Molecular biology of the cell 22, 17 (2011): 3231-41. Details. Full text
  • Zhu, F.;Parthasarathy, R.;Bai, H.;Woithe, K.;Kaussmann, M.;Nauen, R.;Harrison, DA ;Palli, SR "A brain-specific cytochrome P450 responsible for the majority of deltamethrin resistance in the QTC279 strain of Tribolium castaneum." Proceedings of the National Academy of Sciences of the United States of America 107, 19 (2010): 8557-62. Details. Full text
  • Harrison, DA "Sex determination: controlling the master." Current biology : CB 17, 9 (2007): R328-30. Details. Full text
  • Harrison, SM ;Harrison, DA "Contrasting mechanisms of stem cell maintenance in Drosophila." Seminars in cell & developmental biology 17, 4 (2006): 518-33. Details. Full text
  • Harrison, SM ;Rudolph, JL ;Spencer, ML ;Wes, PD ;Montell, C.;Andres, DA ;Harrison, DA "Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development." Developmental dynamics : an official publication of the American Association of Anatomists 232, 3 (2005): 817-26. Details. Full text
  • Xing, B.;Ashleigh Long, A.;Harrison, DA ;Cooper, RL "Developmental consequences of neuromuscular junctions with reduced presynaptic calcium channel function." Synapse (New York, N.Y.) 57, 3 (2005): 132-47. Details.
  • Rawlings, JS ;Rosler, KM ;Harrison, DA "The JAK/STAT signaling pathway." Journal of cell science 117, Pt 8 (2004): 1281-3. Details. Full text
  • Rawlings, JS ;Rennebeck, G.;Harrison, SM ;Xi, R.;Harrison, DA "Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities." BMC cell biology 5, 1 (2004): 38. Details. Full text
  • Harrison, DA ;Cooper, RL "Characterization of development, behavior and neuromuscular physiology in the phorid fly, Megaselia scalaris." Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 136, 2 (2003): 427-39. Details. Full text
  • Xi, R.;McGregor, JR ;Harrison, DA "A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium." Developmental cell 4, 2 (2003): 167-77. Details. Full text
  • McGregor, JR ;Xi, R.;Harrison, DA "JAK signaling is somatically required for follicle cell differentiation in Drosophila." Development (Cambridge, England) 129, 3 (2002): 705-17. Details. Full text
  • Chung, S.;Zhou, Z.;Huddleston, KA ;Harrison, DA ;Reed, R.;Coleman, TA ;Rymond, BC "Crooked neck is a component of the human spliceosome and implicated in the splicing process." Biochimica et biophysica acta 1576, 3 (2002): 287-97. Details. Full text
  • Duffy, JB ;Harrison, DA ;Perrimon, N "Identifying loci required for follicular patterning using directed mosaics." Development (Cambridge, England) 125, 12 (1998): 2263-71. Details. Full text
  • Harrison, DA ;McCoon, PE ;Binari, R ;Gilman, M ;Perrimon, N "Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway." Genes & development 12, 20 (1998): 3252-63. Details. Full text
  • Harrison, DA ;Binari, R ;Nahreini, TS ;Gilman, M ;Perrimon, N "Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects." The EMBO journal 14, 12 (1995): 2857-65. Details.
  • Harrison, DA ;Perrimon, N "Simple and efficient generation of marked clones in Drosophila." Current biology : CB 3, 7 (1993): 424-33. Details. Full text
  • Harrison, DA ;Gdula, DA ;Coyne, RS ;Corces, VG "A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function." Genes & development 7, 10 (1993): 1966-78. Details. Full text
  • Harrison, DA ;Mortin, MA ;Corces, VG "The RNA polymerase II 15-kilodalton subunit is essential for viability in Drosophila melanogaster." Molecular and cellular biology 12, 3 (1992): 928-35. Details. Full text
  • Parkhurst, SM ;Harrison, DA ;Remington, MP ;Spana, C ;Kelley, RL ;Coyne, RS ;Corces, VG "The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein." Genes & development 2, 10 (1988): 1205-15. Details. Full text
  • Spana, C ;Harrison, DA ;Corces, VG "The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon." Genes & development 2, 11 (1988): 1414-23. Details. Full text
  • Harrison, DA ;Geyer, PK ;Spana, C ;Corces, VG "The gypsy retrotransposon of Drosophila melanogaster: mechanisms of mutagenesis and interaction with the suppressor of Hairy-wing locus." Developmental genetics 10, 3 (0): 239-48. Details.
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