Jeremy Van Cleve

jva238's picture
  • Associate Professor
  • Behavior
  • Bioinformatics and Computational Biology
  • Biology
  • Ecology and Evolutionary Biology
  • Genetics and Genomics
THM 216
(859) 218-3020
Research Interests:

B.A. Oberlin College 2003
Ph.D. Stanford University 2009

My current research falls into three topics
  • Evolution of cooperation in groups

    Although the evolutionary forces that can support the spread of cooperative or mutually beneficial social interactions are fairly well understood, a systematic framework for how to explore proximate mechanisms for such cooperation that is amenable to evolutionary analysis is lacking.  In collaboration with Erol Akçay, I have developed a system of studying behavioral objectives that can clarify the ecological requirements for cooperative interactions.

  • Evolution in variable environments and bet-hedging

    I have explored the role of trade offs and fitness asymmetries can have on the conditions for the evolution of bet-hedging.  This is of particular relevance to microbial evolution as many microbiologists see random variations in gene expression, a kind of bet-hedging, as a common way for microbes to adapt to variable environments.

  • Evolution of genomic imprinting

    Using tools from population genetics and evolutionary theory, I have explored factors that could explain the evolution of imprinting including genetic interactions such as dominance and a host of demographic factors including sex-specific selection, sex-specific migration, and generation overlap.  I have also studied the dynamic effects of imprinting, which include the possibility of complex dynamics and chaos.

PubMed Publications*: 
  • McGlothlin, JW ;Akçay, E ;Brodie, ED ;Moore, AJ ;Van Cleve, J "A Synthesis of Game Theory and Quantitative Genetic Models of Social Evolution." The Journal of heredity 113, 1 (2022): 109-119. Details. Full text
  • Van Cleve, J "Building a synthetic basis for kin selection and evolutionary game theory using population genetics." Theoretical population biology 133, (2020): 65-70. Details. Full text
  • Estrela, S ;Libby, E ;Van Cleve, J ;Débarre, F ;Deforet, M ;Harcombe, WR ;Pena, J ;Brown, SP ;Hochberg, ME "Environmentally Mediated Social Dilemmas." Trends in ecology & evolution 34, 1 (2019): 6-18. Details. Full text
  • Altenberg, L ;Creanza, N ;Fogarty, L ;Hadany, L ;Kolodny, O ;Laland, KN ;Lehmann, L.;Otto, SP ;Rosenberg, NA ;Van Cleve, J ;Wakeley, J "Some topics in theoretical population genetics: Editorial commentaries on a selection of Marc Feldman's TPB papers." Theoretical population biology 129, (2019): 4-8. Details. Full text
  • Ramachandran, S.;Otto, SP ;Uyenoyama, M ;Van Cleve, J ""Any news?" Special issue in honor of Marcus Feldman's 75th birthday." Theoretical population biology 129, (2019): 1-3. Details. Full text
  • Van Cleve, J "Stags, Hawks, and Doves: Social Evolution Theory and Individual Variation in Cooperation." Integrative and comparative biology 57, 3 (2017): 566-579. Details. Full text
  • Akçay, E ;Van Cleve, J "There is no fitness but fitness, and the lineage is its bearer." Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371, 1687 (2016): 20150085. Details. Full text
  • Van Cleve, J "Cooperation, conformity, and the coevolutionary problem of trait associations." Journal of theoretical biology 396, (2016): 13-24. Details. Full text
  • Wilkins, JF ;Ubeda, F.;Van Cleve, J "The evolving landscape of imprinted genes in humans and mice: Conflict among alleles, genes, tissues, and kin." BioEssays : news and reviews in molecular, cellular and developmental biology 38, 5 (2016): 482-9. Details. Full text
  • Lehmann, L.;Mullon, C ;Akçay, E ;Van Cleve, J "Invasion fitness, inclusive fitness, and reproductive numbers in heterogeneous populations." Evolution; international journal of organic evolution 70, 8 (2016): 1689-702. Details.
  • Van Cleve, J ;Weissman, DB "Measuring ruggedness in fitness landscapes." Proceedings of the National Academy of Sciences of the United States of America 112, 24 (2015): 7345-6. Details. Full text
  • Van Cleve, J "Social evolution and genetic interactions in the short and long term." Theoretical population biology 103, (2015): 2-26. Details. Full text
  • Servedio, MR ;Brandvain, Y ;Dhole, S ;Fitzpatrick, CL ;Goldberg, EE ;Stern, CA ;Van Cleve, J ;Yeh, DJ "Not just a theory--the utility of mathematical models in evolutionary biology." PLoS biology 12, 12 (2014): e1002017. Details. Full text
  • Van Cleve, J ;Akçay, E "Pathways to social evolution: reciprocity, relatedness, and synergy." Evolution; international journal of organic evolution 68, 8 (2014): 2245-58. Details.
  • Van Cleve, J ;Lehmann, L. "Stochastic stability and the evolution of coordination in spatially structured populations." Theoretical population biology 89, (2013): 75-87. Details. Full text
  • Akçay, E ;Van Cleve, J "Behavioral responses in structured populations pave the way to group optimality." The American naturalist 179, 2 (2012): 257-69. Details. Full text
  • Brandvain, Y ;Van Cleve, J ;Ubeda, F.;Wilkins, JF "Demography, kinship, and the evolving theory of genomic imprinting." Trends in genetics : TIG 27, 7 (2011): 251-7. Details. Full text
  • Liberman, U ;Van Cleve, J ;Feldman, MW "On the evolution of mutation in changing environments: recombination and phenotypic switching." Genetics 187, 3 (2011): 837-51. Details. Full text
  • Van Cleve, J ;Feldman, MW ;Lehmann, L. "How demography, life history, and kinship shape the evolution of genomic imprinting." The American naturalist 176, 4 (2010): 440-55. Details. Full text
  • Akçay, E ;Van Cleve, J ;Feldman, MW ;Roughgarden, J "A theory for the evolution of other-regard integrating proximate and ultimate perspectives." Proceedings of the National Academy of Sciences of the United States of America 106, 45 (2009): 19061-6. Details. Full text
  • Salathé, M ;Van Cleve, J ;Feldman, MW "Evolution of stochastic switching rates in asymmetric fitness landscapes." Genetics 182, 4 (2009): 1159-64. Details. Full text
  • Van Cleve, J ;Feldman, MW "Stable long-period cycling and complex dynamics in a single-locus fertility model with genomic imprinting." Journal of mathematical biology 57, 2 (2008): 243-64. Details. Full text
  • Van Cleve, J ;Feldman, MW "Sex-specific viability, sex linkage and dominance in genomic imprinting." Genetics 176, 2 (2007): 1101-18. Details. Full text
  • Tate, AT ;Van Cleve, J "Bet-hedging in innate and adaptive immune systems." Evolution, medicine, and public health 10, 1 (0): 256-265. Details. Full text
* Publications are automatically pulled from based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.