Vincent Cassone

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Education: 
BA in English and Biology, Colby College, 1975 MS in Biobehavioral Sciences, University of Connecticut, 1977 Ph.D. University of Oregon., 1983
Research: 

Chronobiology and Neuroscience

Research in the Cassone laboratory is directed at the mechanisms and neuroendocrine pathways by which the biological clock regulates physiology and behavior in  vertebrates, especially in birds. All eukaryotic and at least some prokaryotic organisms express a temporal organization as well as a spatial organization such that many molecular, physiological and behavioral events are strictly timed. This temporal organization reflects a biological clock derived primarily from endogenous cellular oscillators that are somehow coupled or entrained to the prevailing environmental cycles. Students in the laboratory are encouraged to develop independent projects based upon scientific questions within the framework of the laboratory's mission. Weekly lab meetings and personal supervision of laboratory projects help to integrate technically diverse but philosophically intimate graduate and undergraduate research.

Functional Genomics of the Avian Circadian Clock: The avian pineal gland is a circadian oscillator and photoreceptor, which regulates birds' physiology and behavior via the secretion of the hormone melatonin. While the molecular mechanisms underlying melatonin biosynthesis have been largely worked out, the molecular clockworks regulating circadian rhythms, the photoentrainment of these rhythms to environmental light cycles and the link of the oscillators and photoreceptors to rhythmic outputs. We are studying the mechanisms by which molecular clockworks regulate these physiological outputs ranging from metabolism to complex behavior.

Circadian and Seasonal Regulation of Bird Song: Bird song is one of the few non-human forms of syntactical and contextual of animal communication. Bird song is regulated by a complex of brain structures collectively called the "song control system". We have found that song control brain structures express melatonin receptors and that bird song behavior and bird song control structures are regulated on a daily and seasonal basis by pineal melatonin. We are studying the mechanisms by which melatonin and the circadian system synchronizes bird song to the time of day and the time of year. We are also interested in mechanisms by which bird song itself may feed back on circadian sleep/wake cycles in birds.

Circadian Regulation of Gastrointestinal Function: We have established that there is a semi-independent circadian oscillator within the gastrointestinal system. This system is synchronized to external time through the action of the hypothalamic suprachiasmatic nuclei (SCN) , which communicate to peripheral organs through the sympathetic autonomic nervous system. Our current interests involve investigations of other modulators of gastrointestinal rhythmicity and of the impact of circadian clocks on diseased states and normal aging.

PubMed Publications*: 
  • Wang, G.;Harpole, CE ;Paulose, J ;Cassone, VM "The role of the pineal gland in the photoperiodic control of bird song frequency and repertoire in the house sparrow, Passer domesticus." Hormones and behavior 65, 4 (2014): 372-379. Details. Full text
  • Cassone, VM "Avian circadian organization: a chorus of clocks." Frontiers in neuroendocrinology 35, 1 (2014): 76-88. Details. Full text
  • Wang, G.;Harpole, CE ;Trivedi, AK ;Cassone, VM "Circadian regulation of bird song, call, and locomotor behavior by pineal melatonin in the zebra finch." Journal of biological rhythms 27, 2 (2012): 145-55. Details. Full text
  • Malloy, JN ;Paulose, JK ;Li, Y.;Cassone, VM "Circadian rhythms of gastrointestinal function are regulated by both central and peripheral oscillators." American journal of physiology. Gastrointestinal and liver physiology 303, 4 (2012): G461-73. Details. Full text
  • Cassone, VM ;Westneat, DF "The bird of time: cognition and the avian biological clock." Frontiers in molecular neuroscience 5, (2012): 32. Details. Full text
  • Hoogerwerf, WA ;Shahinian, VB ;Cornélissen, G.;Halberg, F.;Bostwick, J.;Timm, J.;Bartell, PA ;Cassone, VM "Rhythmic changes in colonic motility are regulated by period genes." American journal of physiology. Gastrointestinal and liver physiology 298, 2 (2010): G143-50. Details. Full text
  • Cassone, VM ;Paulose, JK ;Whitfield-Rucker, MG ;Peters, JL "Time's arrow flies like a bird: two paradoxes for avian circadian biology." General and comparative endocrinology 163, 1-2 (2009): 109-16. Details. Full text
  • Paulose, JK ;Peters, JL ;Karaganis, SP ;Cassone, VM "Pineal melatonin acts as a circadian zeitgeber and growth factor in chick astrocytes." Journal of pineal research 46, 3 (2009): 286-94. Details. Full text
  • Qu, X.;Metz, RP ;Porter, WW ;Cassone, VM ;Earnest, DJ "Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver." Toxicology and applied pharmacology 234, 3 (2009): 370-7. Details. Full text
  • Clerico, EM ;Cassone, VM ;Golden, SS "Stability and lability of circadian period of gene expression in the cyanobacterium Synechococcus elongatus." Microbiology (Reading, England) 155, Pt 2 (2009): 635-41. Details. Full text
  • Karaganis, SP ;Bartell, PA ;Shende, VR ;Moore, AF ;Cassone, VM "Modulation of metabolic and clock gene mRNA rhythms by pineal and retinal circadian oscillators." General and comparative endocrinology 161, 2 (2009): 179-92. Details. Full text
  • Hoogerwerf, WA ;Sinha, M.;Conesa, A.;Luxon, BA ;Shahinian, VB ;Cornélissen, G.;Halberg, F.;Bostwick, J.;Timm, J.;Cassone, VM "Transcriptional profiling of mRNA expression in the mouse distal colon." Gastroenterology 135, 6 (2008): 2019-29. Details. Full text
  • Cassone, VM ;Bartell, PA ;Earnest, BJ ;Kumar, V. "Duration of melatonin regulates seasonal changes in song control nuclei of the house sparrow, Passer domesticus: independence from gonads and circadian entrainment." Journal of biological rhythms 23, 1 (2008): 49-58. Details. Full text
  • Karaganis, SP ;Kumar, V.;Beremand, PD ;Bailey, MJ ;Thomas, TL ;Cassone, VM "Circadian genomics of the chick pineal gland in vitro." BMC genomics 9, (2008): 206. Details. Full text
  • Qu, X.;Metz, RP ;Porter, WW ;Cassone, VM ;Earnest, DJ "Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland." Molecular pharmacology 72, 5 (2007): 1349-58. Details. Full text
  • Menger, GJ ;Allen, GC ;Neuendorff, N.;Nahm, SS ;Thomas, TL ;Cassone, VM ;Earnest, DJ "Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN." Physiological genomics 29, 3 (2007): 280-9. Details. Full text
  • Hoogerwerf, WA ;Hellmich, HL ;Cornélissen, G.;Halberg, F.;Shahinian, VB ;Bostwick, J.;Savidge, TC ;Cassone, VM "Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen." Gastroenterology 133, 4 (2007): 1250-60. Details. Full text
  • Golden, SS ;Cassone, VM ;LiWang, A. "Shifting nanoscopic clock gears." Nature structural & molecular biology 14, 5 (2007): 362-3. Details. Full text
  • Cantwell, EL ;Cassone, VM "Chicken suprachiasmatic nuclei: II. Autoradiographic and immunohistochemical analysis." The Journal of comparative neurology 499, 3 (2006): 442-57. Details. Full text
  • Cantwell, EL ;Cassone, VM "Chicken suprachiasmatic nuclei: I. Efferent and afferent connections." The Journal of comparative neurology 496, 1 (2006): 97-120. Details. Full text
  • Peters, JL ;Cassone, VM "Melatonin regulates circadian electroretinogram rhythms in a dose- and time-dependent fashion." Journal of pineal research 38, 3 (2005): 209-15. Details. Full text
  • Peters, JL ;Earnest, BJ ;Tjalkens, RB ;Cassone, VM ;Zoran, MJ "Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific." The Journal of comparative neurology 493, 3 (2005): 370-80. Details. Full text
  • Menger, GJ ;Lu, K.;Thomas, T.;Cassone, VM ;Earnest, DJ "Circadian profiling of the transcriptome in immortalized rat SCN cells." Physiological genomics 21, 3 (2005): 370-81. Details. Full text
  • Bailey, MJ ;Cassone, VM "Melanopsin expression in the chick retina and pineal gland." Brain research. Molecular brain research 134, 2 (2005): 345-8. Details. Full text
  • Peters, JL ;Cassone, VM ;Zoran, MJ "Melatonin modulates intercellular communication among cultured chick astrocytes." Brain research 1031, 1 (2005): 10-9. Details. Full text
  • Bell-Pedersen, D.;Cassone, VM ;Earnest, DJ ;Golden, SS ;Hardin, PE ;Thomas, TL ;Zoran, MJ "Circadian rhythms from multiple oscillators: lessons from diverse organisms." Nature reviews. Genetics 6, 7 (2005): 544-56. Details. Full text
  • Bailey, MJ ;Beremand, PD ;Hammer, R.;Reidel, E.;Thomas, TL ;Cassone, VM "Transcriptional profiling of circadian patterns of mRNA expression in the chick retina." The Journal of biological chemistry 279, 50 (2004): 52247-54. Details. Full text
  • Bailey, MJ ;Cassone, VM "Opsin photoisomerases in the chick retina and pineal gland: characterization, localization, and circadian regulation." Investigative ophthalmology & visual science 45, 3 (2004): 769-75. Details. Full text
  • Bailey, MJ ;Beremand, PD ;Hammer, R.;Bell-Pedersen, D.;Thomas, TL ;Cassone, VM "Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillator and pacemaker." Molecular endocrinology (Baltimore, Md.) 17, 10 (2003): 2084-95. Details. Full text
  • Bailey, MJ ;Chong, NW ;Xiong, J.;Cassone, VM "Chickens' Cry2: molecular analysis of an avian cryptochrome in retinal and pineal photoreceptors." FEBS letters 513, 2-3 (2002): 169-74. Details. Full text
  • Cassone, VM ;Stephan, FK "Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: implications for nutrition during manned space flight." Nutrition (Burbank, Los Angeles County, Calif.) 18, 10 (2002): 814-9. Details. Full text
  • Cantwell, EL ;Cassone, VM "Daily and circadian fluctuation in 2-deoxy (14)C -glucose uptake in circadian and visual system structures of the chick brain: effects of exogenous melatonin." Brain research bulletin 57, 5 (2002): 603-11. Details. Full text
  • Adachi, A.;Natesan, AK ;Whitfield-Rucker, MG ;Weigum, SE ;Cassone, VM "Functional melatonin receptors and metabolic coupling in cultured chick astrocytes." Glia 39, 3 (2002): 268-78. Details. Full text
  • Allen, G.;Rappe, J.;Earnest, DJ ;Cassone, VM "Oscillating on borrowed time: diffusible signals from immortalized suprachiasmatic nucleus cells regulate circadian rhythmicity in cultured fibroblasts." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 20 (2001): 7937-43. Details. Full text
  • Whitfield-Rucker, M.;Cassone, VM "Photoperiodic regulation of the male house sparrow song control system: gonadal dependent and independent mechanisms." General and comparative endocrinology 118, 1 (2000): 173-83. Details. Full text
  • Cassone, VM "The self-same beat of time's wide wings." Proceedings of the National Academy of Sciences of the United States of America 97, 22 (2000): 11677-9. Details. Full text
  • Wu, WQ ;McGoogan, JM ;Cassone, VM "Circadian regulation of visually evoked potentials in the domestic pigeon, Columba livia." Journal of biological rhythms 15, 4 (2000): 317-28. Details. Full text
  • Morien, A.;Cassone, VM ;Wellman, PJ "Diurnal changes in paraventricular hypothalamic alpha1 and alpha2-adrenoceptors and food intake in rats." Pharmacology, biochemistry, and behavior 63, 1 (1999): 33-8. Details. Full text
  • McGoogan, JM ;Cassone, VM "Circadian regulation of chick electroretinogram: effects of pinealectomy and exogenous melatonin." The American journal of physiology 277, 5 Pt 2 (1999): R1418-27. Details. Full text
  • Earnest, DJ ;Liang, FQ ;Ratcliff, M.;Cassone, VM "Immortal time: circadian clock properties of rat suprachiasmatic cell lines." Science (New York, N.Y.) 283, 5402 (1999): 693-5. Details. Full text
  • Cassone, VM "Melatonin's role in vertebrate circadian rhythms." Chronobiology international 15, 5 (1998): 457-73. Details.
  • Chong, NW ;Cassone, VM ;Bernard, M.;Klein, DC ;Iuvone, PM "Circadian expression of tryptophan hydroxylase mRNA in the chicken retina." Brain research. Molecular brain research 61, 1-2 (1998): 243-50. Details.
  • Salter, JM ;Cassone, VM ;Wilkerson, MK ;Delp, MD "Ocular and regional cerebral blood flow in aging Fischer-344 rats." Journal of applied physiology (Bethesda, Md. : 1985) 85, 3 (1998): 1024-9. Details. Full text
  • Cassone, VM ;Natesan, AK "Time and time again: the phylogeny of melatonin as a transducer of biological time." Journal of biological rhythms 12, 6 (1997): 489-97. Details.
  • Bernard, M.;Iuvone, PM ;Cassone, VM ;Roseboom, PH ;Coon, SL ;Klein, DC "Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina." Journal of neurochemistry 68, 1 (1997): 213-24. Details. Full text
  • Whitfield-Rucker, MG ;Cassone, VM "Melatonin binding in the house sparrow song control system: sexual dimorphism and the effect of photoperiod." Hormones and behavior 30, 4 (1996): 528-37. Details. Full text
  • Reppert, SM ;Weaver, DR ;Cassone, VM ;Godson, C.;Kolakowski LF, Jr "Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain." Neuron 15, 5 (1995): 1003-15. Details. Full text
  • Warren, WS ;Cassone, VM "The pineal gland: photoreception and coupling of behavioral, metabolic, and cardiovascular circadian outputs." Journal of biological rhythms 10, 1 (1995): 64-79. Details. Full text
  • Lü, J.;Zoran, MJ ;Cassone, VM "Daily and circadian variation in the electroretinogram of the domestic fowl: effects of melatonin." Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 177, 3 (1995): 299-306. Details.
  • Janik, D.;Cassone, VM ;Pickard, GE ;Menaker, M. "Retinohypothalamic projections and immunocytochemical analysis of the suprachiasmatic region of the desert iguana Dipsosaurus dorsalis." Cell and tissue research 275, 3 (1994): 399-406. Details.
  • Warren, WS ;Champney, TH ;Cassone, VM "The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system." Physiology & behavior 55, 6 (1994): 1091-9. Details.
  • Brooks, DS ;Cassone, VM "Daily and circadian regulation of 2- 125I iodomelatonin binding in the chick brain." Endocrinology 131, 3 (1992): 1297-304. Details. Full text
  • Cassone, VM "Effects of melatonin on vertebrate circadian systems." Trends in neurosciences 13, 11 (1990): 457-64. Details. Full text
  • Cassone, VM ;Forsyth, AM ;Woodlee, GL "Hypothalamic regulation of circadian noradrenergic input to the chick pineal gland." Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 167, 2 (1990): 187-92. Details.
  • Smale, L.;Cassone, VM ;Moore, RY ;Morin, LP "Paraventricular nucleus projections mediating pineal melatonin and gonadal responses to photoperiod in the hamster." Brain research bulletin 22, 2 (1989): 263-9. Details. Full text
  • Shibata, S.;Cassone, VM ;Moore, RY "Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro." Neuroscience letters 97, 1-2 (1989): 140-4. Details. Full text
  • Rivkees, SA ;Cassone, VM ;Weaver, DR ;Reppert, SM "Melatonin receptors in chick brain: characterization and localization." Endocrinology 125, 1 (1989): 363-8. Details. Full text
  • Cassone, VM ;Roberts, MH ;Moore, RY "Effects of melatonin on 2-deoxy- 1-14C glucose uptake within rat suprachiasmatic nucleus." The American journal of physiology 255, 2 Pt 2 (1988): R332-7. Details. Full text
  • Cassone, VM "Circadian variation of 14C 2-deoxyglucose uptake within the suprachiasmatic nucleus of the house sparrow, Passer domesticus." Brain research 459, 1 (1988): 178-82. Details. Full text
  • Cassone, VM ;Roberts, MH ;Moore, RY "Melatonin inhibits metabolic activity in the rat suprachiasmatic nuclei." Neuroscience letters 81, 1-2 (1987): 29-34. Details. Full text
  • Cassone, VM ;Moore, RY "Retinohypothalamic projection and suprachiasmatic nucleus of the house sparrow, Passer domesticus." The Journal of comparative neurology 266, 2 (1987): 171-82. Details.
  • Chesworth, MJ ;Cassone, VM ;Armstrong, SM "Effects of daily melatonin injections on activity rhythms of rats in constant light." The American journal of physiology 253, 1 Pt 2 (1987): R101-7. Details. Full text
  • Cassone, VM ;Takahashi, JS ;Blaha, CD ;Lane, RF ;Menaker, M. "Dynamics of noradrenergic circadian input to the chicken pineal gland." Brain research 384, 2 (1986): 334-41. Details. Full text
  • Cassone, VM ;Menaker, M. "Is the avian circadian system a neuroendocrine loop?" The Journal of experimental zoology 232, 3 (1984): 539-49. Details.
  • Cassone, VM ;Menaker, M. "Sympathetic regulation of chicken pineal rhythms." Brain research 272, 2 (1983): 311-7. Details. Full text
  • Cassone, VM ;Lane, RF ;Menaker, M. "Daily rhythms of serotonin metabolism in the medial hypothalamus of the chicken: effects of pinealectomy and exogenous melatonin." Brain research 289, 1-2 (1983): 129-34. Details. Full text
  • Cassone, VM ;Chesworth, MJ ;Armstrong, SM "Dose-dependent entrainment of rat circadian rhythms by daily injection of melatonin." Journal of biological rhythms 1, 3 (1969): 219-29. Details. Full text
  • Cassone, VM "Circadian organization and photoreception in an Australian dasyurid marsupial (Sminthopsis macroura)." Journal of biological rhythms 2, 4 (1969): 261-8. Details. Full text
  • Cassone, VM "The pineal gland influences rat circadian activity rhythms in constant light." Journal of biological rhythms 7, 1 (1969): 27-40. Details. Full text
  • Natesan, AK ;Cassone, VM "Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus." Visual neuroscience 19, 3 (1969): 265-74. Details. Full text
  • Warren, WS ;Hodges, DB ;Cassone, VM "Pinealectomized rats entrain and phase-shift to melatonin injections in a dose-dependent manner." Journal of biological rhythms 8, 3 (1969): 233-45. Details. Full text
  • Iuvone, PM ;Bernard, M.;Alonso-Gomez, A.;Greve, P.;Cassone, VM ;Klein, DC "Cellular and molecular regulation of serotonin N-acetyltransferase activity in chicken retinal photoreceptors." Biological signals 6, 4-6 (1969): 217-24. Details.
  • Cassone, VM ;Speh, JC ;Card, JP ;Moore, RY "Comparative anatomy of the mammalian hypothalamic suprachiasmatic nucleus." Journal of biological rhythms 3, 1 (1969): 71-91. Details. Full text
  • Armstrong, SM ;Cassone, VM ;Chesworth, MJ ;Redman, JR ;Short, RV "Synchronization of mammalian circadian rhythms by melatonin." Journal of neural transmission. Supplementum 21, (0): 375-94. Details.
  • Cassone, VM ;Westneat, DF "The bird of time: cognition and the avian biological clock." Frontiers in molecular neuroscience 5, (0): 32. Details. Full text
  • Cassone, VM "Melatonin: time in a bottle." Oxford reviews of reproductive biology 12, (0): 319-67. Details.
  • Cassone, VM ;Warren, WS ;Brooks, DS ;Lü, J. "Melatonin, the pineal gland, and circadian rhythms." Journal of biological rhythms 8 Suppl, (0): S73-81. Details.
  • Paulose, JK ;Rucker EB, 3rd ;Cassone, VM "Toward the beginning of time: circadian rhythms in metabolism precede rhythms in clock gene expression in mouse embryonic stem cells." PloS one 7, 11 (0): e49555. Details. Full text
  • Klein, DC ;Coon, SL ;Roseboom, PH ;Weller, JL ;Bernard, M.;Gastel, JA ;Zatz, M.;Iuvone, PM ;Rodriguez, IR ;Bégay, V.;Falcón, J.;Cahill, GM ;Cassone, VM ;Baler, R. "The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland." Recent progress in hormone research 52, (0): 307-57; discussion 357-8. Details.
  • Cassone, VM ;Lane, RF ;Menaker, M. "Melatonin-induced increases in serotonin concentrations in specific regions of the chicken brain." Neuroendocrinology 42, 1 (0): 38-43. Details.
  • Cassone, VM ;Chesworth, MJ ;Armstrong, SM "Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei." Physiology & behavior 36, 6 (0): 1111-21. Details.
  • McGoogan, JM ;Wu, WQ ;Cassone, VM "Inter-ocular interference and circadian regulation of the chick electroretinogram." Vision research 40, 20 (0): 2869-79. Details. Full text
  • Allen, GC ;Farnell, Y.;Bell-Pedersen, D.;Cassone, VM ;Earnest, DJ "Effects of altered Clock gene expression on the pacemaker properties of SCN2.2 cells and oscillatory properties of NIH/3T3 cells." Neuroscience 127, 4 (0): 989-99. Details. Full text
  • Earnest, DJ ;Cassone, VM "Cell culture models for oscillator and pacemaker function: recipes for dishes with circadian clocks?" Methods in enzymology 393, (0): 558-78. Details. Full text
  • Cassone, VM ;Brooks, DS ;Kelm, TA "Comparative distribution of 2 125I iodomelatonin binding in the brains of diurnal birds: outgroup analysis with turtles." Brain, behavior and evolution 45, 5 (0): 241-56. Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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