Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics



Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms.  Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites.  Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations.  Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications.  To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data.  This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.

TITLE: Square roots of divergence form operators on L^p spaces

ABSTRACT: An abstract is available online at

http://www.ms.uky.edu/~kott/PDEseminarf13/Haller-Dintelmann.pdf

A talk by Kathleen Fitzpatrick, Professor of Media Studies, Ponoma College and Director of Scholarly Communication, Modern Language Association. What if the academic monograph is a dying form? If scholarly communication is to have a future, it's clear that it lies online, and yet the most significant obstacles to such a transformation are not technological, but instead social and institutional. How must the academy and the scholars that comprise it change their ways of thinking in order for digital scholarly publishing to become a viable alternative to the university press book? This talk will explore some of those changes and their implications for our lives as scholars and our work within universities.