Click here for more information about Dr. Sarah Tishkoff.

Abstract:

Africa is thought to be the ancestral homeland of all modern human populations.  It is also a region of tremendous cultural, linguistic, climatic, and genetic diversity.   Despite the important role that African populations have played in human history, they remain one of the most underrepresented groups in human genomics studies. A comprehensive knowledge of patterns of variation in African genomes is critical for a deeper understanding of human genomic diversity, the identification of functionally important genetic variation, the genetic basis of adaptation to diverse environments and diets, and for reconstructing modern human origins. African populations practice diverse subsistence patterns (hunter-gatherers, pastoralists, agriculturalists, and agro-pastoralists) and live in diverse environments with differing pathogen exposure (tropical forest, savannah, coastal, desert, low altitude, and high altitude) and, therefore, are likely to have experienced local adaptation. In this talk I will discuss results of analyses of genome-scale genetic variation in geographically, linguistically, and ethnically diverse African populations in order to reconstruct human evolutionary history in Africa, African and African American ancestry, as well as the genetic basis of adaption to diverse environments.

Dr. Christopher Vulpe | Vulpe Lab

Bio: 
Chris Vulpe, MD, PhD. is a Professor at the University of Florida, Gainesville in the Center for Environmental
and Human Toxicology. Dr. Vulpe received his MD and PhD from the University of California, San Francisco.
Dr. Vulpe’s group uses systems level approaches in eukaryotes from yeast to people to identify the functional
components that respond to and modulate the consequences of environmental stressors. Most recently, his laboratory is utilizing genome wide and targeted CRISPR screens to understand the mechanisms of toxicity of environmental chemicals. Dr. Vulpe is an author or co-author on >175 papers in peer reviewed journals and books. His group uses functional, genomic, and genetic approaches to provide insight into mechanisms of toxicity in diverse model systems including human models such as human cell culture, organoids, and rodents, as well as ecologically relevant organisms such as Daphnia magna.