Sheldon Steiner

  • Professor
  • Biochemistry Biophysics and Structural Biology
  • Biology
  • Cell and Developmental Biology
  • Microbiology
319a TH Morgan Bldg.
(859) 257-3870

Ph.D. University of Kentucky, 1967


Neuron Astrocyte Signal Transduction

The long term goal of studies in my laboratory is to understand the role of lipid biomediators, in neuronal degeneration. Lipid biomediators include a wide range of compounds such as prostaglandins, leukotrienes, platelet activating factor lysophosphatidic acid (LPA), tumor necrosis factor and various cytokines. Currently, we are examining the role of LPA in signaling pathways associated with neuronal degeneration (apoptosis) as a model for Alzheimers disease and head trauma. We utilize primary neurons primary astrocytes, primary microglial cells and immortalized neuronally derived cultures cells (for gene transfer studies) as our model systems. These studies suggest that lipid biomediators, in particular LPA likely play a role in neuronal degeneration.

PubMed Publications*: 
  • Steiner, MR ;Urso, JR ;Klein, J.;Steiner, SM "Multiple astrocyte responses to lysophosphatidic acids." Biochimica et biophysica acta 1582, 1-3 (2002): 154-60. Details. Full text
  • Steiner, MR ;Holtsberg, FW ;Keller, JN ;Mattson, MP ;Steiner, SM "Lysophosphatidic acid induction of neuronal apoptosis and necrosis." Annals of the New York Academy of Sciences 905, (2000): 132-41. Details. Full text
  • Guo, Q.;Fu, W.;Holtsberg, FW ;Steiner, SM ;Mattson, MP "Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations." Journal of neuroscience research 56, 5 (1999): 457-70. Details. Full text
  • Bruce-Keller, AJ ;Geddes, JW ;Knapp, PE ;McFall, RW ;Keller, JN ;Holtsberg, FW ;Parthasarathy, S.;Steiner, SM ;Mattson, MP "Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD." Journal of neuroimmunology 93, 1-2 (1999): 53-71. Details.
  • Keller, JN ;Kindy, MS ;Holtsberg, FW ;St Clair, DK ;Yen, HC ;Germeyer, A.;Steiner, SM ;Bruce-Keller, AJ ;Hutchins, JB ;Mattson, MP "Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction." The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 2 (1998): 687-97. Details. Full text
  • Holtsberg, FW ;Steiner, MR ;Bruce-Keller, AJ ;Keller, JN ;Mattson, MP ;Moyers, JC ;Steiner, SM "Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells." Journal of neuroscience research 53, 6 (1998): 685-96. Details. Full text
  • Holtsberg, FW ;Steiner, MR ;Keller, JN ;Mark, RJ ;Mattson, MP ;Steiner, SM "Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons." Journal of neurochemistry 70, 1 (1998): 66-76. Details. Full text
  • Holtsberg, FW ;Steiner, MR ;Furukawa, K.;Keller, JN ;Mattson, MP ;Steiner, SM "Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium." Journal of neurochemistry 69, 1 (1997): 68-75. Details. Full text
  • Keller, JN ;Steiner, MR ;Holtsberg, FW ;Mattson, MP ;Steiner, SM "Lysophosphatidic acid-induced proliferation-related signals in astrocytes." Journal of neurochemistry 69, 3 (1997): 1073-84. Details. Full text
  • Keller, JN ;Steiner, MR ;Mattson, MP ;Steiner, SM "Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes." Journal of neurochemistry 67, 6 (1996): 2300-5. Details. Full text
  • Steiner, SM ;Hu, Y.;Steiner, MR "Regulation of prostaglandin H synthase 1 and 2 in MyoD transfected cells." Experimental cell research 218, 1 (1995): 389-93. Details. Full text
  • Goodman, Y.;Steiner, MR ;Steiner, SM ;Mattson, MP "Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation." Brain research 654, 1 (1994): 171-6. Details. Full text
  • Wolf, JR ;Hu, Y.;Hirschhorn, RR ;Steiner, SM "MyoD and regulation of prostaglandin H synthase." Experimental cell research 207, 2 (1993): 439-41. Details. Full text
  • Wolf, JR ;Hirschhorn, RR ;Steiner, SM "Growth factor responsiveness: role of MyoD and myogenin." Experimental cell research 202, 1 (1992): 105-12. Details. Full text
  • Steiner, SM ;Keutzer, JC ;Hirschhorn, RR "Prostaglandin endoperoxide synthase (cyclooxygenase) mRNA and protein production in mouse myoblasts and a differentiation-defective variant." Experimental cell research 192, 2 (1991): 643-6. Details.
  • Rossi, MJ ;Clark, MA ;Steiner, SM "Possible role of prostaglandins in the regulation of mouse myoblasts." Journal of cellular physiology 141, 1 (1989): 142-7. Details. Full text
  • Morton, PA ;Steiner, SM "Extracellular and cellular proteins of rat cells with O-glycosidically linked fucose." The Biochemical journal 225, 1 (1985): 59-65. Details. Full text
  • Steiner, SM ;Morton, PA "Metabolism of a transformation-sensitive amino acid fucoside in normal and simian virus 40-transformed human embryonic lung cells." Cancer research 44, 10 (1984): 4476-9. Details. Full text
  • Morton, PA ;Klinger, MM ;Steiner, SM "Characterization of an amino acid fucoside of normal and SV40-transformed human embryonic lung cells." Cancer research 42, 8 (1982): 3022-7. Details. Full text
  • Klinger, MM ;Laine, RA ;Steiner, SM "Characterization of novel amino acid fucosides." The Journal of biological chemistry 256, 15 (1981): 7932-5. Details. Full text
  • Gubish ER, Jr ;Mace ML, Jr ;Steiner, SM ;Williams, RP "Assessment of attachment of Neisseria gonorrhoeae to HeLa cells by double radiolabeling." Infection and immunity 25, 3 (1979): 1043-50. Details. Full text
  • Brennan, PJ ;Steiner, SM ;Courtney, RJ ;Skelly, J. "Metabolism of galactose in herpes simplex virus-infected cells." Virology 69, 1 (1976): 216-28. Details. Full text
  • Steiner, SM ;Melnick, JL ;Kit, S.;Somers, KD "Fucosylglycolipids in cells transformed by a temperature-sensitive mutant of murine sarcoma virus." Nature 248, 5450 (1974): 682-4. Details.
  • Courtney, RJ ;Steiner, SM ;Benyesh-Melnick, M. "Effects of 2-deoxy-D-glucose on herpes simplex virus replication." Virology 52, 2 (1973): 447-55. Details.
  • Rossi, MJ ;Clark, MA ;Steiner, SM "Possible role of prostaglandins in the regulation of mouse myoblasts." Progress in clinical and biological research 343, (0): 29-40. Details.
* Publications are automatically pulled from based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.
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